5 Result(s)
within
Esteban Ballestar
Biomedicine
Medicine/Public Health, general
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Article
Open AccessEpigenetic and transcriptomic reprogramming in monocytes of severe COVID-19 patients reflects alterations in myeloid differentiation and the influence of inflammatory cytokines
COVID-19 manifests with a wide spectrum of clinical phenotypes, ranging from asymptomatic and mild to severe and critical. Severe and critical COVID-19 patients are characterized by marked changes in the myelo...
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Article
Open AccessEpigenomics and transcriptomics of systemic sclerosis CD4+ T cells reveal long-range dysregulation of key inflammatory pathways mediated by disease-associated susceptibility loci
Systemic sclerosis (SSc) is a genetically complex autoimmune disease mediated by the interplay between genetic and epigenetic factors in a multitude of immune cells, with CD4+ T lymphocytes as one of the princ...
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Article
Open AccessInflammatory cytokines and organ dysfunction associate with the aberrant DNA methylome of monocytes in sepsis
Sepsis, a life-threatening organ dysfunction caused by a dysregulated systemic immune response to infection, associates with reduced responsiveness to subsequent infections. How such tolerance is acquired is n...
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Chapter
Disruption of Epigenetic Mechanisms in Autoimmune Syndromes
Autoimmune disorders are a heterogeneous group of both systemic and organ-specific diseases characterized by the abnormal recognition of self-components by the immune system. These are genetically complex dise...
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Article
Open AccessEpigenetic alterations in autoimmune disease
