13 Result(s)
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Eduardo Andrés-León
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Article
Open AccessCortistatin deficiency reveals a dysfunctional brain endothelium with impaired gene pathways, exacerbated immune activation, and disrupted barrier integrity
Brain activity governing cognition and behaviour depends on the fine-tuned microenvironment provided by a tightly controlled blood–brain barrier (BBB). Brain endothelium dysfunction is a hallmark of BBB breakd...
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Article
Open AccessSingle-cell Atlas of common variable immunodeficiency shows germinal center-associated epigenetic dysregulation in B-cell responses
Common variable immunodeficiency (CVID), the most prevalent symptomatic primary immunodeficiency, displays impaired terminal B-cell differentiation and defective antibody responses. Incomplete genetic penetran...
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Article
Open AccessSelective histone methyltransferase G9a inhibition reduces metastatic development of Ewing sarcoma through the epigenetic regulation of NEU1
Ewing sarcoma (EWS) is an aggressive bone and soft tissue tumor with high susceptibility to metastasize. The underlying molecular mechanisms leading to EWS metastases remain poorly understood. Epigenetic chang...
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Article
Open AccessSelective inhibition of HDAC6 regulates expression of the oncogenic driver EWSR1-FLI1 through the EWSR1 promoter in Ewing sarcoma
Ewing sarcoma (EWS) is an aggressive bone and soft tissue tumor of children and young adults in which the principal driver is a fusion gene, EWSR1-FLI1. Although the essential role of EWSR1-FLI1 protein in the re...
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Protocol
NGS Methodologies and Computational Algorithms for the Prediction and Analysis of Plant Circular RNAs
Circular RNAs (circRNAs) are a class of single-stranded RNAs derived from exonic, intronic, and intergenic regions from precursor messenger RNAs (pre-mRNA), where a noncanonical back-splicing event occurs, in ...
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Article
Open AccessEpigenomics and transcriptomics of systemic sclerosis CD4+ T cells reveal long-range dysregulation of key inflammatory pathways mediated by disease-associated susceptibility loci
Systemic sclerosis (SSc) is a genetically complex autoimmune disease mediated by the interplay between genetic and epigenetic factors in a multitude of immune cells, with CD4+ T lymphocytes as one of the princ...
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Open AccessDetection of novel fusion-transcripts by RNA-Seq in T-cell lymphoblastic lymphoma
Fusions transcripts have been proven to be strong drivers for neoplasia-associated mutations, although their incidence in T-cell lymphoblastic lymphoma needs to be determined yet. Using RNA-Seq we have selecte...
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Article
Open AccessCD38 promotes pristane-induced chronic inflammation and increases susceptibility to experimental lupus by an apoptosis-driven and TRPM2-dependent mechanism
In this study, we investigated the role of CD38 in a pristane-induced murine model of lupus. CD38-deficient (Cd38−/−) but not ART2-deficient (Art2−/−) mice developed less severe lupus compared to wild type (WT) m...
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Article
Open AccessCorrection: Corrigendum: miARma-Seq: a comprehensive tool for miRNA, mRNA and circRNA analysis
Scientific Reports 6: Article number: 25749; published online: 11 May 2016; updated: 08 January 2018 This Article contains out-of-date links to the miARma-Seq workflow webpages in the Methods section. Therefor...
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Chapter
RNA sequencing and Prediction Tools for Circular RNAs Analysis
Circular RNAs (circRNAs) are noncoding and single-stranded RNA transcripts able to form covalently circular-closed structures. They are generated through alternative splicing events and widely expressed from h...
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Article
Open AccessNovel miRNA-mRNA interactions conserved in essential cancer pathways
Cancer is a complex disease in which unrestrained cell proliferation results in tumour development. Extensive research into the molecular mechanisms underlying tumorigenesis has led to the characterization of ...
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Protocol
Prediction of miRNA–mRNA Interactions Using miRGate
miRGate (http://mirgate.bioinfo.cnio.es/) is a freely available database that contains predicted and experimentally validated microRNA–messenger RNA (miRNA–mRNA) t...
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Article
Open AccessmiARma-Seq: a comprehensive tool for miRNA, mRNA and circRNA analysis
Large-scale RNAseq has substantially changed the transcriptomics field, as it enables an unprecedented amount of high resolution data to be acquired. However, the analysis of these data still poses a challenge...
