-
Article
Open AccessPlatelet and mitochondrial RNA is decreased in plasma-derived extracellular vesicles in women with preeclampsia—an exploratory study
Circulating extracellular vesicles (EVs) are increased in preeclampsia (PE) and are associated with severity and progression. We examined in this exploratory cohort study if the mRNAs and long noncoding RNAs (...
-
Article
Metabolic dysfunction-associated fatty liver disease as a risk factor for adverse outcomes in subsequent pregnancy: a nationwide cohort study
A recent international expert consensus opinion suggested that metabolic dysfunction-associated fatty liver disease (MAFLD) replaces nonalcoholic fatty liver disease (NAFLD), since MAFLD is a better predictor ...
-
Article
Open AccessDevelopment of early prediction model for pregnancy-associated hypertension with graph-based semi-supervised learning
Clinical guidelines recommend several risk factors to identify women in early pregnancy at high risk of develo** pregnancy-associated hypertension. However, these variables result in low predictive accuracy....
-
Article
Open AccessAuthor Correction: Dysregulated non-coding telomerase RNA component and associated exonuclease XRN1 in leucocytes from women develo** preeclampsia-possible link to enhanced senescence
-
Article
Open AccessMaternal dyslipidemia and altered cholesterol metabolism in early pregnancy as a risk factor for small for gestational age neonates
We evaluated the relationship between maternal cholesterol levels and its biologically active precursors and metabolites in the first trimester and subsequent risk for small-for-gestational-age birthweight (SG...
-
Article
Open AccessDysregulated non-coding telomerase RNA component and associated exonuclease XRN1 in leucocytes from women develo** preeclampsia-possible link to enhanced senescence
Senescence in placenta/fetal membranes is a normal phenomenon linked to term parturition. However, excessive senescence which may be induced by telomere attrition, has been associated with preeclampsia (PE). W...
-
Article
Open AccessCharacterization of miR-200 family members as blood biomarkers for human and laying hen ovarian cancer
MicroRNA-200 (miR-200) family is highly expressed in ovarian cancer. We evaluated the levels of family members relative to the internal control miR-103a in ovarian cancer and control blood specimens collected ...
-
Article
Open AccessMetabolomic biomarkers in midtrimester maternal plasma can accurately predict the development of preeclampsia
Early identification of patients at risk of develo** preeclampsia (PE) would allow providers to tailor their prenatal management and adopt preventive strategies, such as low-dose aspirin. Nevertheless, no mi...
-
Article
Endometriosis: The Role of Iron Overload and Ferroptosis
Iron is an essential element for cell survival, and iron deficiency is a known risk factor for many reproductive disorders. Paradoxically, such disorders are also seen more commonly under conditions of iron ex...
-
Article
Open AccessMetabolic Biomarkers In Midtrimester Maternal Plasma Can Accurately Predict Adverse Pregnancy Outcome in Patients with SLE
Patients with systemic lupus erythematosus (SLE) are at increased risk for adverse pregnancy outcome (APO). Accurate prediction of APO is critical to identify, counsel, and manage these high-risk patients. We ...
-
Article
Open AccessIncreased biosynthesis and accumulation of cholesterol in maternal plasma, but not amniotic fluid in pre-eclampsia
Preeclampsia is one of the most serious complications during pregnancy, defined as development of hypertension during late pregnancy affecting other organ systems (proteinuria, thrombocytopenia, renal insuffic...
-
Article
Non-alcoholic fatty liver disease in the first trimester and subsequent development of gestational diabetes mellitus
Although there is substantial evidence that non-alcoholic fatty liver disease (NAFLD) is associated with impaired glucose homeostasis, the clinical significance of NAFLD in pregnant women has not been well det...
-
Article
Open AccessPrediction of Gestational Diabetes Mellitus and Pre-diabetes 5 Years Postpartum using 75 g Oral Glucose Tolerance Test at 14–16 Weeks’ Gestation
Early detection and treatment of women at risk for gestational diabetes mellitus (GDM) could improve perinatal and long-term outcomes in GDM women and their offspring. We explored if a 75 g oral glucose tolera...
-
Article
Open AccessGene expression in term placentas is regulated more by spinal or epidural anesthesia than by late-onset preeclampsia or gestational diabetes mellitus
Pre-eclampsia (PE) and gestational diabetes mellitus (GDM) are common complications of pregnancy, but the mechanisms underlying these disorders remain unclear. The aim was to identify the extent of altered gen...
-
Article
Impact of Systemic Inflammation on the Progression of Gestational Diabetes Mellitus
With increasing rates of obesity and new diagnostic criteria for gestational diabetes mellitus (GDM), the overall prevalence of GDM is increasing worldwide. Women with GDM have an increased risk of maternal an...
-
Article
Open AccessLow circulating pentraxin 3 levels in pregnancy is associated with gestational diabetes and increased apoB/apoA ratio: a 5-year follow-up study
Gestational diabetes mellitus (GDM) is a significant risk factor for cardiovascular disease (CVD) in later life. Pentraxin 3 (PTX3) is an essential component of innate immunity and independently associated wit...
-
Article
Clustering of monozygotic twinning in IVF
The aim of this analysis was to study whether monozygotic twinning (MZT) events occur in clusters after IVF and, if so, to explore possible explanations for this clustering.
-
Article
Maternal Infection in Pregnancy and Risk of Asthma in Offspring
This study estimates the effect of maternal infections during pregnancy on childhood asthma. One-thousand four-hundred and twenty-eight pregnant women were prospectively followed using structured interviews an...
-
Article
Must maternity medicine be reborn?
-
Chapter
Preterm Labor
Although the ability of obstetric care providers to identify women at risk for preterm birth has improved during the past three decades, there are as yet no effective strategies available for the prevention or...
