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Open AccessThe preterm gut microbiota and administration routes of different probiotics: a randomized controlled trial
Preterm children with their aberrant gut microbiota and susceptibility to infections and inflammation constitute a considerable target group for probiotic therapy to generate the age-appropriate healthy microb...
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Article
Open AccessSpontaneous preterm delivery is reflected in both early neonatal and maternal gut microbiota
Aberrant gut microbiota composition in preterm neonates is linked to adverse health consequences. Little is known about the impact of perinatal factors or maternal gut microbiota on initial preterm gut coloniz...
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Article
Open AccessNeonatal antibiotic exposure impairs child growth during the first six years of life by perturbing intestinal microbial colonization
Exposure to antibiotics in the first days of life is thought to affect various physiological aspects of neonatal development. Here, we investigate the long-term impact of antibiotic treatment in the neonatal p...
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The impact of probiotic supplementation during pregnancy on DNA methylation of obesity-related genes in mothers and their children
Dietary supplementation with probiotics during pregnancy has been suggested to decrease the risk for obesity in women after delivery and to minimize excessive weight gain in their children. Epigenetic DNA meth...
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Article
Perinatal nutrition impacts on the functional development of the visual tract in infants
We investigated the associations of maternal diet and serum fatty acids during pregnancy and in early infancy on infantile neurodevelopment.
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Open AccessMaternal gut and breast milk microbiota affect infant gut antibiotic resistome and mobile genetic elements
The infant gut microbiota has a high abundance of antibiotic resistance genes (ARGs) compared to adults, even in the absence of antibiotic exposure. Here we study potential sources of infant gut ARGs by perfor...
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Open AccessProceedings of the 2017 WAO Symposium on Hot Topics in Allergy: Pediatric & Regulatory Aspects
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Open AccessA cross-sectional comparative study of gut bacterial community of Indian and Finnish children
The human gut microbiome plays a crucial role in the compositional development of gut microbiota. Though well documented in western pediatrics population, little is known about how various host conditions affe...
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Article
Open AccessHuman gut colonisation may be initiated in utero by distinct microbial communities in the placenta and amniotic fluid
Interaction with intestinal microbes in infancy has a profound impact on health and disease in later life through programming of immune and metabolic pathways. We collected maternal faeces, placenta, amniotic ...
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Article
Bifidobacterium animalis subsp. lactis BB-12 in reducing the risk of infections in early childhood
Specific probiotic bacteria have proven to be effective in the prevention and treatment of infectious diseases in early life in at-risk populations. The impact of administration of Bifidobacterium animalis subsp....
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Probiotic Lactobacillus rhamnosus GG therapy and microbiological programming in infantile colic: a randomized, controlled trial
Probiotic Lactobacillus reuteri and reduced allergen load may lessen the daily crying of colic infants, but the role of Lactobacillus rhamnosus GG (LGG) has remained obscure.
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A possible link between early probiotic intervention and the risk of neuropsychiatric disorders later in childhood: a randomized trial
Recent experimental evidence suggests that gut microbiota may alter function within the nervous system providing new insight on the mechanism of neuropsychiatric disorders.
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Lactobacillus rhamnosus GG and its SpaC pilus adhesin modulate inflammatory responsiveness and TLR-related gene expression in the fetal human gut
Bacterial contact in utero modulates fetal and neonatal immune responses. Maternal probiotic supplementation reduces the risk of immune-mediated disease in the infant. We investigated the immunomodulatory propert...
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Gut microbiota: a source of novel tools to reduce the risk of human disease?
Modern civilization is faced with a progressive increase in immune-mediated or inflammatory health problems such as allergic disease, autoimmune disorders, and obesity. An extended version of the hygiene hypot...
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Is There a Role for Probiotics in the Prevention or Treatment of Food Allergy?
A balanced gut microbiota is crucial for the development of healthy immunoregulation and gut barrier function to allow brisk immune responses to pathogens and systemic hyporesponsiveness to harmless antigens s...
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Open AccessMicroarray analysis reveals marked intestinal microbiota aberrancy in infants having eczema compared to healthy children in at-risk for atopic disease
Deviations in composition and diversity of intestinal microbiota in infancy have been associated with both the development and recurrence of atopic eczema. Thus, we decided to use a deep and global microarray-...
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Microbial contact during pregnancy, intestinal colonization and human disease
The development of the gut microbiota occurs early in life. As outlined in this Review by Isolauri and colleagues, the initial microbial colonization of the gut, and indeed of the rest of the human body, is a ...
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Maternal weight and excessive weight gain during pregnancy modify the immunomodulatory potential of breast milk
Breast milk is an optimal source of nutrition for infants. It contains bioactive components including bacteria that support the microbial colonization and immune system development of the infant. The determina...
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Probiotics and dietary counselling targeting maternal dietary fat intake modifies breast milk fatty acids and cytokines
Breast milk fatty acids possess immunomodulatory properties, and new intervention strategies beyond supplementation of maternal diet with single oils are called for. The objective of the present study was to e...
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Dietary sucrose intake is related to serum leptin concentration in overweight pregnant women
Overweight, characterized by low-degree systemic inflammation, predisposes women to impaired glucose metabolism during pregnancy. Adipokine leptin participates in the regulation of energy balance and immune ac...
