28 Result(s)

Article

Decrease in the rate of secondary amyloidosis in Turkish children with FMF: are we doing better?

Familial Mediterranean fever (FMF) is the most common autoinflammatory disease in the world. The most serious complication of FMF is the development of secondary amyloidosis. Besides genetic factors, environme...

Victoria Akse-Önal, Erdal Sağ, Seza Ozen… in European Journal of Pediatrics (2010)

Chapter

A Rare Cause of Elevated Chitotriosidase Activity: Glycogen Storage Disease Type IV

Human chitinolytic enzyme named “chitotriosidase” takes part in the defense mechanism against pathogens and the homeostasis of innate immunity. Chitotriosidase was firstly reported to be markedly high in plasm...

Hayriye Hizarcioglu-Gulsen, Aysel Yuce, Zuhal Akcoren… in JIMD Reports, Volume 17 (2014)

Article

Autoinflammatory Diseases with Periodic Fevers

One purpose of this review was to raise awareness for the new autoinflammatory syndromes. These diseases are increasingly recognized and are in the differential diagnosis of many disease states. We also aimed ...

Erdal Sag, Yelda Bilginer, Seza Ozen in Current Rheumatology Reports (2017)

Article

A new biopsychosocial and clinical questionnaire to assess juvenile idiopathic arthritis: JAB-Q

To create a new multidimensional questionnaire for the assessment of juvenile idiopathic arthritis (JIA) patients in standard clinical practice and study the validity and reliability of this questionnaire.

Edibe Unal, Ezgi Deniz Batu, Hafize Emine Sonmez… in Rheumatology International (2018)

Article

Is age associated with disease severity and compliance to treatment in children with familial Mediterranean fever?

Familial Mediterranean Fever (FMF) is the most common monogenic autoinflammatory disease in the world. The disease characteristics may vary in different age groups. In this study, we aimed to compare disease c...

Hafize Emine Sönmez, Pelin Esmeray, Ezgi Deniz Batu… in Rheumatology International (2019)

Article

The factors affecting the disease course in Kawasaki disease

The aim of this study was to review the characteristics of patients with Kawasaki disease (KD) from Turkey and to assess the performance of the Kobayashi score (KS), Harada score (HS), Formosa score (FS), Egam...

Elif Arslanoglu Aydin, Ilker Ertugrul, Yelda Bilginer… in Rheumatology International (2019)

Chapter

Behçet Disease

Behçet disease (BD) is a multisystemic autoinflammatory disorder of unknown etiology. BD is most common along the historical Silk Road from Far East Asia to the Mediterranean region. The disease is characteriz...

Erdal Sag, Yelda Bilginer, Seza Ozen in Periodic and Non-Periodic Fevers (2020)

Article

Clusters in Pediatric Rheumatic Diseases

Rheumatic diseases usually have very diverse and complex pathophysiology resulting in different clinical phenotypes. Some certain phenotypes cluster together with a common presentation, course, and outcome. Ou...

Erdal Sag, Selcan Demir, Seza Ozen in Current Rheumatology Reports (2020)

Article

Epigenetics for Clinicians from the Perspective of Pediatric Rheumatic Diseases

Epigenetics is the study of inherited phenotype changes that do not involve in alteration of DNA sequence. Epigenetic regulation can be examined under three main headings and study methodologies for all three ...

Tayfun Hilmi Akbaba, Erdal Sag, Banu Balci-Peynircioglu… in Current Rheumatology Reports (2020)

Article

Ancient familial Mediterranean fever mutations in human pyrin and resistance to Yersinia pestis

Familial Mediterranean fever (FMF) is an autoinflammatory disease caused by homozygous or compound heterozygous gain-of-function mutations in MEFV, which encodes pyrin, an inflammasome protein. Heterozygous carri...

Yong Hwan Park, Elaine F. Remmers, Wonyong Lee, Amanda K. Ombrello… in Nature Immunology (2020)

Article

Inflammatory milieu of muscle biopsies in juvenile dermatomyositis

Juvenile dermatomyositis (JDM) is an inflammatory myopathy which causes severe morbidity and high mortality if untreated. In this study, we aimed to define the T-helper cell profile in the muscle biopsies of J...

Erdal Sag, Gulsev Kale, Goknur Haliloglu, Yelda Bilginer… in Rheumatology International (2021)

Article

Performances of the “MS-score” And “HScore” in the diagnosis of macrophage activation syndrome in systemic juvenile idiopathic arthritis patients

Macrophage activation syndrome (MAS) is a devastating complication of systemic JIA (sJIA), seen in approximately 10–25% of the sJIA patients. A number of criteria have been proposed to differentiate between ac...

Erdal Sag, Armagan Keskin, Erdal Atalay, Selcan Demir… in Rheumatology International (2021)

Article

ECI Biocommentary: Erdal Sag

Erdal Sag in Pediatric Research (2021)

Article

Juvenile idiopathic arthritis: lymphocyte activation gene-3 is a central immune receptor in children with oligoarticular subtypes

We investigated the role of inhibitory receptors (IRs) and especially lymphocyte activation gene-3 (LAG-3) in the pathogenesis of oligoarticular juvenile idiopathic arthritis (o-JIA).

Erdal Sag, Selcan Demir, Maithri Aspari, Morten Aagaard Nielsen… in Pediatric Research (2021)