28 Result(s)

Article

Chronic non-bacterial osteomyelitis and immune checkpoint molecules

We aimed to investigate the plasma levels and cell surface expression of two checkpoint molecules, TIM-3 (T cell immunoglobulin and mucin domain–containing protein 3) and PD-1 (programmed cell death protein 1)...

Ummusen Kaya Akca, Erdal Sag, Busra Aydın, Nur Kubra Tasdemir… in Clinical Rheumatology (2024)

Article

Pediatric mixed connective tissue disease versus other overlap syndromes: a retrospective multicenter cohort study

Pediatric mixed connective tissue disease (MCTD) is a subgroup of overlap syndromes. We aimed to compare the characteristics and outcomes in children with MCTD and other overlap syndromes. All MCTD patients me...

Ezgi Deniz Batu, Aybüke Günalp, Sezgin Şahin, Semanur Özdel… in Rheumatology International (2023)

Article

Assessment of systemic and ocular inflammation in juvenile idiopathic arthritis via choroidal vascularity index

We aimed to evaluate the retina and the choroid in children with juvenile idiopathic arthritis (JIA) employing optical coherence tomography (OCT). This cross-sectional study, carried out between June 2017–Dece...

Abdullah Ağın, Sibel Kadayıfçılar, Ata Baytaroğlu… in Rheumatology International (2022)

Article

Spinal involvement in juvenile idiopathic arthritis: what do we miss without imaging?

Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease of childhood. Enthesitis-related arthritis (ERA) has been one of the most controversial subtypes of JIA with a higher risk of ax...

Selcan Demir, Fatma Bilge Ergen, Onur Taydaş, Erdal Sağ… in Rheumatology International (2022)

Article

Comparison of IVIG resistance predictive models in Kawasaki disease

We aimed to compare the ten different scores (by Kobayashi, Egami, Harada, Formosa, Sano, Piram et al., Wu et al., Yang et al., Tan et al., and Kanai et al.) to assess their performance in predicting IVIG resi...

Ummusen Kaya Akca, Elif Arslanoglu Aydin, Hayrettin Hakan Aykan… in Pediatric Research (2022)

Article

Real-world data on MTX tolerance with regimens used in children versus adults

Methotrexate (MTX) is one of the most commonly used disease-modifying anti-rheumatic drugs which can cause gastrointestinal side effects. MTX intolerance is defined as gastrointestinal and behavioral symptoms ...

Ummusen Kaya Akca, Bayram Farisogullari, Gozde Kubra Yardimci… in Clinical Rheumatology (2021)

Article

ECI Biocommentary: Erdal Sag

Erdal Sag in Pediatric Research (2021)

Article

Juvenile idiopathic arthritis: lymphocyte activation gene-3 is a central immune receptor in children with oligoarticular subtypes

We investigated the role of inhibitory receptors (IRs) and especially lymphocyte activation gene-3 (LAG-3) in the pathogenesis of oligoarticular juvenile idiopathic arthritis (o-JIA).

Erdal Sag, Selcan Demir, Maithri Aspari, Morten Aagaard Nielsen… in Pediatric Research (2021)

Article

Inflammatory milieu of muscle biopsies in juvenile dermatomyositis

Juvenile dermatomyositis (JDM) is an inflammatory myopathy which causes severe morbidity and high mortality if untreated. In this study, we aimed to define the T-helper cell profile in the muscle biopsies of J...

Erdal Sag, Gulsev Kale, Goknur Haliloglu, Yelda Bilginer… in Rheumatology International (2021)

Article

Performances of the “MS-score” And “HScore” in the diagnosis of macrophage activation syndrome in systemic juvenile idiopathic arthritis patients

Macrophage activation syndrome (MAS) is a devastating complication of systemic JIA (sJIA), seen in approximately 10–25% of the sJIA patients. A number of criteria have been proposed to differentiate between ac...

Erdal Sag, Armagan Keskin, Erdal Atalay, Selcan Demir… in Rheumatology International (2021)

Article

Ancient familial Mediterranean fever mutations in human pyrin and resistance to Yersinia pestis

Familial Mediterranean fever (FMF) is an autoinflammatory disease caused by homozygous or compound heterozygous gain-of-function mutations in MEFV, which encodes pyrin, an inflammasome protein. Heterozygous carri...

Yong Hwan Park, Elaine F. Remmers, Wonyong Lee, Amanda K. Ombrello… in Nature Immunology (2020)

Article

Epigenetics for Clinicians from the Perspective of Pediatric Rheumatic Diseases

Epigenetics is the study of inherited phenotype changes that do not involve in alteration of DNA sequence. Epigenetic regulation can be examined under three main headings and study methodologies for all three ...

Tayfun Hilmi Akbaba, Erdal Sag, Banu Balci-Peynircioglu… in Current Rheumatology Reports (2020)

Article

Clusters in Pediatric Rheumatic Diseases

Rheumatic diseases usually have very diverse and complex pathophysiology resulting in different clinical phenotypes. Some certain phenotypes cluster together with a common presentation, course, and outcome. Ou...

Erdal Sag, Selcan Demir, Seza Ozen in Current Rheumatology Reports (2020)

Chapter

Behçet Disease

Behçet disease (BD) is a multisystemic autoinflammatory disorder of unknown etiology. BD is most common along the historical Silk Road from Far East Asia to the Mediterranean region. The disease is characteriz...

Erdal Sag, Yelda Bilginer, Seza Ozen in Periodic and Non-Periodic Fevers (2020)

Article

The factors affecting the disease course in Kawasaki disease

The aim of this study was to review the characteristics of patients with Kawasaki disease (KD) from Turkey and to assess the performance of the Kobayashi score (KS), Harada score (HS), Formosa score (FS), Egam...

Elif Arslanoglu Aydin, Ilker Ertugrul, Yelda Bilginer… in Rheumatology International (2019)

Article

Is age associated with disease severity and compliance to treatment in children with familial Mediterranean fever?

Familial Mediterranean Fever (FMF) is the most common monogenic autoinflammatory disease in the world. The disease characteristics may vary in different age groups. In this study, we aimed to compare disease c...

Hafize Emine Sönmez, Pelin Esmeray, Ezgi Deniz Batu… in Rheumatology International (2019)