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Article
Open AccessType I interferon shapes brain distribution and tropism of tick-borne flavivirus
Viral tropism within the brain and the role(s) of vertebrate immune response to neurotropic flaviviruses infection is largely understudied. We combine multimodal imaging (cm-nm scale) with single nuclei RNA-se...
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Article
Open AccessLiver saturated fat content associates with hepatic DNA methylation in obese individuals
Accumulation of saturated fatty acids (SFAs) in the liver is known to induce hepatic steatosis and inflammation causing non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). Altho...
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Article
Open AccessAdipose methylome integrative-omic analyses reveal genetic and dietary metabolic health drivers and insulin resistance classifiers
There is considerable evidence for the importance of the DNA methylome in metabolic health, for example, a robust methylation signature has been associated with body mass index (BMI). However, visceral fat (VF...
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Article
Open AccessLarge scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities
Viral proteins make extensive use of short peptide interaction motifs to hijack cellular host factors. However, most current large-scale methods do not identify this important class of protein-protein interact...
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Article
Open AccessVPS39-deficiency observed in type 2 diabetes impairs muscle stem cell differentiation via altered autophagy and epigenetics
Insulin resistance and lower muscle quality (strength divided by mass) are hallmarks of type 2 diabetes (T2D). Here, we explore whether alterations in muscle stem cells (myoblasts) from individuals with T2D co...
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Chapter and Conference Paper
Are My Employees Able to and Do They Want to Work? The Baseline Investigation in a Follow up Study Regarding Managers’ Attitudes and Measures to Increase Employees’ Employability in an Extended Working Life
Background: The demographic change affects the retirement age, which has been postponed in many countries. Therefore, the number of senior employees is increasing in the world. However, managers’ attitudes toward...
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Chapter and Conference Paper
Management, Measures and Maintenance: Success and Setbacks in Interventions Promoting a Healthy and Sustainable Employability and Working Life for All Ages
Background: The labour force is ageing due to the demographic change and the postponement of old-age retirement in many countries.
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Article
Open AccessCompetitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells
Circulating monocytes can compete for virtually any tissue macrophage niche and become long-lived replacements that are phenotypically indistinguishable from their embryonic counterparts. As the factors regula...
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Article
Open AccessA Single Bout of Electroacupuncture Remodels Epigenetic and Transcriptional Changes in Adipose Tissue in Polycystic Ovary Syndrome
A single bout of electroacupuncture results in muscle contractions and increased whole body glucose uptake in women with polycystic ovary syndrome (PCOS). Women with PCOS have transcriptional and epigenetic al...
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Article
Open AccessDNA methylation links genetics, fetal environment, and an unhealthy lifestyle to the development of type 2 diabetes
Type 2 diabetes is a complex trait with both environmental and hereditary factors contributing to the overall pathogenesis. One link between genes, environment, and disease is epigenetics influencing gene tran...
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Article
Open AccessDiabetes medication associates with DNA methylation of metformin transporter genes in the human liver
Given that metformin is the most common pharmacological therapy for type 2 diabetes, understanding the function of this drug is of great importance. Hepatic metformin transporters are responsible for the pharm...
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Article
Open AccessAbnormal epigenetic changes during differentiation of human skeletal muscle stem cells from obese subjects
Human skeletal muscle stem cells are important for muscle regeneration. However, the combined genome-wide DNA methylation and expression changes taking place during adult myogenesis have not been described in ...
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Article
Open AccessThe role of the poly(A) tract in the replication and virulence of tick-borne encephalitis virus
The tick-borne encephalitis virus (TBEV) is a flavivirus transmitted to humans, usually via tick bites. The virus causes tick-borne encephalitis (TBE) in humans, and symptoms range from mild flu-like symptoms ...
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Article
Open AccessDNA methylation and gene expression of HIF3A: cross-tissue validation and associations with BMI and insulin resistance
Associations between BMI and DNA methylation of hypoxia-inducible factor 3-alpha (HIF3A) in both blood cells and subcutaneous adipose tissue (SAT) have been reported. In this study, we investigated associations b...
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Article
Open AccessErratum: Epigenetic and Transcriptional Alterations in Human Adipose Tissue of Polycystic Ovary Syndrome
Scientific Reports 6: Article number: 22883; Published online: 15 March 2016; Updated: 09 May 2016 This Article contains errors. In Table 3, the text in the first row ‘Down-regulated genes’ was incorrectly giv...
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Article
Adipose tissue transcriptomics and epigenomics in low birthweight men and controls: role of high-fat overfeeding
Individuals who had a low birthweight (LBW) are at an increased risk of insulin resistance and type 2 diabetes when exposed to high-fat overfeeding (HFO). We studied genome-wide mRNA expression and DNA methyla...
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Article
Open AccessEpigenetic and Transcriptional Alterations in Human Adipose Tissue of Polycystic Ovary Syndrome
Genetic and epigenetic factors may predispose women to polycystic ovary syndrome (PCOS), a common heritable disorder of unclear etiology. Here we investigated differences in genome-wide gene expression and DNA...
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Article
Open AccessGlucose tolerance is associated with differential expression of microRNAs in skeletal muscle: results from studies of twins with and without type 2 diabetes
We aimed to identify microRNAs (miRNAs) associated with type 2 diabetes and risk of develo** the disease in skeletal muscle biopsies from phenotypically well-characterised twins.
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Article
Delivery Outcome after Maternal Use of Drugs for Migraine
Background: The use of drugs for migraine during pregnancy may have adverse effects on delivery outcome, and warnings exist for such drugs regarding use during pregnancy. Most information in the ...
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Article
Antidepressant use during pregnancy: comparison of data obtained from a prescription register and from antenatal care records
To compare interview data on drug use during pregnancy with data identified from a register of prescriptions.
