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Article
Association of Dynamic Trajectories of Time-Series Data and Life-Threatening Mass Effect in Large Middle Cerebral Artery Stroke
Life-threatening, space-occupying mass effect due to cerebral edema and/or hemorrhagic transformation is an early complication of patients with middle cerebral artery stroke. Little is known about longitudinal...
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Article
Open AccessAssociation of large core middle cerebral artery stroke and hemorrhagic transformation with hospitalization outcomes
Historically, investigators have not differentiated between patients with and without hemorrhagic transformation (HT) in large core ischemic stroke at risk for life-threatening mass effect (LTME) from cerebral ed...
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Article
Open AccessIncidence and prognostic significance of newly-diagnosed atrial fibrillation among older U.S. veterans hospitalized with COVID-19
Most prior studies on the prognostic significance of newly-diagnosed atrial fibrillation (AF) in COVID-19 did not differentiate newly-diagnosed AF from pre-existing AF. To determine the association between new...
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Article
Open AccessCOVID-19 pandemic and initiation of treatment for atrial fibrillation: a nationwide analysis of claims data
The COVID-19 pandemic profoundly disrupted the delivery of medical care. It remains unclear whether individuals diagnosed with new onset disease during the pandemic were less likely to initiate treatments afte...
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Article
The bidirectional association between atrial fibrillation and myocardial infarction
Atrial fibrillation (AF) is associated with an increased risk of myocardial infarction (MI) and vice versa. This bidirectional association relies on shared risk factors as well as on several direct and indirec...
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Article
Open AccessPsychosocial stressors and current e-cigarette use in the youth risk behavior survey
This study explores the association between psychosocial stressors and current e-cigarette use among adolescents in the United States.
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Article
Open AccessFactors associated with long-term use of digital devices in the electronic Framingham Heart Study
Long-term use of digital devices is critical for successful clinical or research use, but digital health studies are challenged by a rapid drop-off in participation. A nested e-cohort (eFHS) is embedded in the...
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Article
Open AccessGenetic diversity fuels gene discovery for tobacco and alcohol use
Tobacco and alcohol use are heritable behaviours associated with 15% and 5.3% of worldwide deaths, respectively, due largely to broad increased risk for disease and injury1–4. These substances are used across the...
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Article
Open AccessThe association between eicosanoids and incident atrial fibrillation in the Framingham Heart Study
Chronic inflammation is a continuous low-grade activation of the systemic immune response. Whereas downstream inflammatory markers are associated with atrial fibrillation (AF), upstream inflammatory effectors ...
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Article
Open AccessPublisher Correction: Endophenotype effect sizes support variant pathogenicity in monogenic disease susceptibility genes
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Article
Open AccessWearable accelerometer-derived physical activity and incident disease
Physical activity is regarded as favorable to health but effects across the spectrum of human disease are poorly quantified. In contrast to self-reported measures, wearable accelerometers can provide more prec...
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Article
Open AccessEndophenotype effect sizes support variant pathogenicity in monogenic disease susceptibility genes
Accurate and efficient classification of variant pathogenicity is critical for research and clinical care. Using data from three large studies, we demonstrate that population-based associations between rare va...
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Article
Natural Language Processing of Radiology Reports to Detect Complications of Ischemic Stroke
Abstraction of critical data from unstructured radiologic reports using natural language processing (NLP) is a powerful tool to automate the detection of important clinical features and enhance research effort...
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Article
Genetic analysis of right heart structure and function in 40,000 people
Congenital heart diseases often involve maldevelopment of the evolutionarily recent right heart chamber. To gain insight into right heart structure and function, we fine-tuned deep learning models to recognize...
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Article
Open AccessThe association between social network index, atrial fibrillation, and mortality in the Framingham Heart Study
Social isolation might be considered as a marker of poor health and higher mortality. The aim of our analysis was to assess the association of social network index (SNI) with incident AF and death. We selected...
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Article
A comparison of statistical methods to predict the residual lifetime risk
Lifetime risk measures the cumulative risk for develo** a disease over one’s lifespan. Modeling the lifetime risk must account for left truncation, the competing risk of death, and inference at a fixed age. ...
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Article
Deep learning enables genetic analysis of the human thoracic aorta
Enlargement or aneurysm of the aorta predisposes to dissection, an important cause of sudden death. We trained a deep learning model to evaluate the dimensions of the ascending and descending thoracic aorta in...
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Article
Social determinants of atrial fibrillation
Atrial fibrillation affects almost 60 million adults worldwide. Atrial fibrillation is associated with a high risk of cardiovascular morbidity and death as well as with social, psychological and economic burde...
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Article
Open AccessTemporal trends in cause-specific mortality among individuals with newly diagnosed atrial fibrillation in the Framingham Heart Study
All-cause mortality following atrial fibrillation (AF) has decreased over time. Data regarding temporal trends in causes of death among individuals with AF are scarce. The aim of our study was to analyze tempo...
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Article
Open AccessSequencing of 53,831 diverse genomes from the NHLBI TOPMed Program
The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate the genetic architecture and biology of heart, lung, blood and sleep disorders, with the ultimate goal of improving diagnosis, treat...
