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Article
Noninvasive assessment of organ-specific and shared pathways in multi-organ fibrosis using T1 map**
Fibrotic diseases affect multiple organs and are associated with morbidity and mortality. To examine organ-specific and shared biologic mechanisms that underlie fibrosis in different organs, we developed machi...
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Article
Open AccessDeep learning of left atrial structure and function provides link to atrial fibrillation risk
Increased left atrial volume and decreased left atrial function have long been associated with atrial fibrillation. The availability of large-scale cardiac magnetic resonance imaging data paired with genetic d...
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Article
Genetics of myocardial interstitial fibrosis in the human heart and association with disease
Myocardial interstitial fibrosis is associated with cardiovascular disease and adverse prognosis. Here, to investigate the biological pathways that underlie fibrosis in the human heart, we developed a machine ...
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Article
Genetic analysis of right heart structure and function in 40,000 people
Congenital heart diseases often involve maldevelopment of the evolutionarily recent right heart chamber. To gain insight into right heart structure and function, we fine-tuned deep learning models to recognize...
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Article
Open AccessCohort design and natural language processing to reduce bias in electronic health records research
Electronic health record (EHR) datasets are statistically powerful but are subject to ascertainment bias and missingness. Using the Mass General Brigham multi-institutional EHR, we approximated a community-bas...
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Article
Open AccessMultimodality Imaging-Based Characterization of Regional Material Properties in a Murine Model of Aortic Dissection
Chronic infusion of angiotensin-II in atheroprone (ApoE−/−) mice provides a reproducible model of dissection in the suprarenal abdominal aorta, often with a false lumen and intramural thrombus that thickens the w...
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Article
Open AccessData-driven Modeling of Hemodynamics and its Role on Thrombus Size and Shape in Aortic Dissections
Aortic dissection is a pathology that manifests due to microstructural defects in the aortic wall. Blood enters the damaged wall through an intimal tear, thereby creating a so-called false lumen and exposing t...
