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Article
Open AccessCaloric restriction leads to druggable LSD1-dependent cancer stem cells expansion
Caloric Restriction (CR) has established anti-cancer effects, but its clinical relevance and molecular mechanism remain largely undefined. Here, we investigate CR’s impact on several mouse models of Acute Myel...
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Article
Open AccessXenoCell: classification of cellular barcodes in single cell experiments from xenograft samples
Single-cell sequencing technologies provide unprecedented opportunities to deconvolve the genomic, transcriptomic or epigenomic heterogeneity of complex biological systems. Its application in samples from xeno...
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Article
Open AccessWDR5 inhibition halts metastasis dissemination by repressing the mesenchymal phenotype of breast cancer cells
Development of metastases and drug resistance are still a challenge for a successful systemic treatment in breast cancer (BC) patients. One of the mechanisms that confer metastatic properties to the cell relie...
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Article
Open AccessExploration of virtual body-representation in adolescence: the role of age and sex in avatar customization
The malleable nature of the self led researchers to investigate the meaning of virtual identity by exploring virtual self-representation through avatars and its association with users’ identity. The present st...
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Article
Open AccessHuman malignant mesothelioma is recapitulated in immunocompetent BALB/c mice injected with murine AB cells
Malignant Mesothelioma is a highly aggressive cancer, which is difficult to diagnose and treat. Here we describe the molecular, cellular and morphological characterization of a syngeneic system consisting of m...
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Article
Open AccessStructural motifs recurring in different folds recognize the same ligand fragments
The structural analysis of protein ligand binding sites can provide information relevant for assigning functions to unknown proteins, to guide the drug discovery process and to infer relations among distant pr...
