13 Result(s)
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Pier Federico Gherardini
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Open AccessCirculating KRAS G12D but not G12V is associated with survival in metastatic pancreatic ductal adenocarcinoma
While high circulating tumor DNA (ctDNA) levels are associated with poor survival for multiple cancers, variant-specific differences in the association of ctDNA levels and survival have not been examined. Here...
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Open AccessSotigalimab and/or nivolumab with chemotherapy in first-line metastatic pancreatic cancer: clinical and immunologic analyses from the randomized phase 2 PRINCE trial
Chemotherapy combined with immunotherapy has improved the treatment of certain solid tumors, but effective regimens remain elusive for pancreatic ductal adenocarcinoma (PDAC). We conducted a randomized phase 2...
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Multiplexed profiling of RNA and protein expression signatures in individual cells using flow or mass cytometry
Advances in single-cell analysis technologies are providing novel insights into phenotypic and functional heterogeneity within seemingly identical cell populations. RNA within single cells can be analyzed usin...
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High response rate to PD-1 blockade in desmoplastic melanomas
Immune checkpoint blockade with anti-PD-1 or anti-PD-L1 agents produces a high response rate in patients with desmoplastic melanoma.
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Highly multiplexed simultaneous detection of RNAs and proteins in single cells
PLAYR (proximity ligation assay for RNA) enables highly multiplexed transcript quantification in combination with protein marker detection in single cells using flow or mass cytometry.
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Correction: Corrigendum: AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation
Nat. Cell Biol. 17, 20–30 (2015); published online 1 December 2014; corrected after print 1 April 2015 In the version of this Article originally published, incorrect western blot scans were provided for the ac...
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AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation
Inhibition of a main regulator of cell metabolism, the protein kinase mTOR, induces autophagy and inhibits cell proliferation. However, the molecular pathways involved in the cross-talk between these two mTOR-...
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Open AccessAlternative splicing tends to avoid partial removals of protein-protein interaction sites
Anecdotal evidence of the involvement of alternative splicing (AS) in the regulation of protein-protein interactions has been reported by several studies. AS events have been shown to significantly occur in re...
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Open AccessIdentification of binding pockets in protein structures using a knowledge-based potential derived from local structural similarities
The identification of ligand binding sites is a key task in the annotation of proteins with known structure but uncharacterized function. Here we describe a knowledge-based method exploiting the observation th...
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Open AccessPhosTryp: a phosphorylation site predictor specific for parasitic protozoa of the family trypanosomatidae
Protein phosphorylation modulates protein function in organisms at all levels of complexity. Parasites of the Leishmania genus undergo various developmental transitions in their life cycle triggered by changes in...
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Open AccessStructural motifs recurring in different folds recognize the same ligand fragments
The structural analysis of protein ligand binding sites can provide information relevant for assigning functions to unknown proteins, to guide the drug discovery process and to infer relations among distant pr...
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Open AccessFunClust: a web server for the identification of structural motifs in a set of non-homologous protein structures
The occurrence of very similar structural motifs brought about by different parts of non homologous proteins is often indicative of a common function. Indeed, relatively small local structures can mediate bind...
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Open AccessFalse occurrences of functional motifs in protein sequences highlight evolutionary constraints
False occurrences of functional motifs in protein sequences can be considered as random events due solely to the sequence composition of a proteome. Here we use a numerical approach to investigate the random a...
