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  1. No Access

    Chapter

    Heparan Sulfate in the Tumor Microenvironment

    The biology of tumor cells strictly depends on their microenvironment architecture and composition, which controls the availability of growth factors and signaling molecules. Thus, the network of glycosaminogl...

    Barbara Bartolini, Elena Caravà, Ilaria Caon, Arianna Parnigoni… in Tumor Microenvironment (2020)

  2. No Access

    Protocol

    Method for Studying ECM Expression: In Situ RT-PCR

    The gene expression of the extracellular matrix macromolecules is critical in the analysis of various pathologies. The use of a RT-PCR directly on a fixed tissue enables the recognition of the real expressing ...

    Elena Caravà, Cristiana Marcozzi, Barbara Bartolini… in The Extracellular Matrix (2019)

  3. No Access

    Article

    MDA-MB-231 breast cancer cell viability, motility and matrix adhesion are regulated by a complex interplay of heparan sulfate, chondroitin−/dermatan sulfate and hyaluronan biosynthesis

    Proteoglycans and glycosaminoglycans modulate numerous cellular processes relevant to tumour progression, including cell proliferation, cell-matrix interactions, cell motility and invasive growth. Among the gl...

    Manuela Viola, Kathrin Brüggemann, Evgenia Karousou, Ilaria Caon… in Glycoconjugate Journal (2017)