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  1. No Access

    Article

    Mutation in TERT separates processivity from anchor-site function

    Repeat-addition processivity (RAP), that is, generating multiple DNA repeats from a single template without primer dissociation, is a key property of telomerase. In the Tetrahymena reverse-transcriptase component...

    Arthur J Zaug, Elaine R Podell, Thomas R Cech in Nature Structural & Molecular Biology (2008)

  2. Article

    Addendum: Crystal structure of the essential N-terminal domain of telomerase reverse transcriptase

    Steven A Jacobs, Elaine R Podell, Thomas R Cech in Nature Structural & Molecular Biology (2007)

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    Article

    The POT1–TPP1 telomere complex is a telomerase processivity factor

    Telomeres were originally defined as chromosome caps that prevent the natural ends of linear chromosomes from undergoing deleterious degradation and fusion events. POT1 (protection of telomeres) protein binds ...

    Feng Wang, Elaine R. Podell, Arthur J. Zaug, Yuting Yang, Paul Baciu… in Nature (2007)

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    Article

    Crystal structure of the essential N-terminal domain of telomerase reverse transcriptase

    Telomerase, a ribonucleoprotein enzyme, adds telomeric DNA repeats to the ends of linear chromosomes. Here we report the first high-resolution structure of any portion of the telomerase reverse transcriptase, ...

    Steven A Jacobs, Elaine R Podell, Thomas R Cech in Nature Structural & Molecular Biology (2006)

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    Article

    Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection

    The POT1 (protection of telomeres 1) protein binds the single-stranded overhang at the ends of chromosomes in diverse eukaryotes. It is essential for chromosome end-protection in the fission yeast Schizosaccharom...

    Ming Lei, Elaine R Podell, Thomas R Cech in Nature Structural & Molecular Biology (2004)

  6. No Access

    Article

    DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA

    Telomeres, specialized protein–DNA complexes that cap the ends of linear chromosomes, are essential for protecting chromosomes from degradation and end-to-end fusions1,2. The Pot1 (protection of telomeres 1) prot...

    Ming Lei, Elaine R. Podell, Peter Baumann, Thomas R. Cech in Nature (2003)