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  1. No Access

    Article

    The AMBRA1 E3 ligase adaptor regulates the stability of cyclin D

    The initiation of cell division integrates a large number of intra- and extracellular inputs. D-type cyclins (hereafter, cyclin D) couple these inputs to the initiation of DNA replication1. Increased levels of cy...

    Andrea C. Chaikovsky, Chuan Li, Edwin E. Jeng, Samuel Loebell, Myung Chang Lee… in Nature (2021)

  2. Article

    Open Access

    Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens

    CRISPR-Cas9 screens are powerful tools for high-throughput interrogation of genome function, but can be confounded by nuclease-induced toxicity at both on- and off-target sites, likely due to DNA damage. Here,...

    David W. Morgens, Michael Wainberg, Evan A. Boyle, Oana Ursu… in Nature Communications (2017)

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  3. No Access

    Article

    Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions

    An improved strategy for large-scale combinatorial CRISPR screening enables the identification of synergistic drug targets for cancer.

    Kyuho Han, Edwin E Jeng, Gaelen T Hess, David W Morgens, Amy Li… in Nature Biotechnology (2017)