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Article
The AMBRA1 E3 ligase adaptor regulates the stability of cyclin D
The initiation of cell division integrates a large number of intra- and extracellular inputs. D-type cyclins (hereafter, cyclin D) couple these inputs to the initiation of DNA replication1. Increased levels of cy...
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Article
Open AccessGenome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens
CRISPR-Cas9 screens are powerful tools for high-throughput interrogation of genome function, but can be confounded by nuclease-induced toxicity at both on- and off-target sites, likely due to DNA damage. Here,...
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Article
Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions
An improved strategy for large-scale combinatorial CRISPR screening enables the identification of synergistic drug targets for cancer.