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Chapter
Structure and Activity of Endotoxins
Gram-negative bacteria comprise a great number of pathogenic microorganisms causing a variety of diseases in mammals, including man. Many of the clinical symptoms observed following an infection with gram-nega...
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Article
Layered murein revisited: a fundamentally new concept of bacterial cell wall structure, biogenesis and function
The classical concept of the architecture of microbial murein assumes cross-linked glycan chains to be arranged in horizontal layers outside of the plasma membrane. It necessitates elaborate hypotheses to exp...
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Chapter
Bacterial Endotoxin: Chemical Constitution, Biological Recognition, Host Response, and Immunological Detoxification
The discovery of endotoxin dates from the late nineteenth century when Richard Pfeiffer, then working in Berlin, characterized endotoxins as heat-stable and cell-associated molecules (Westphal et al. 1977), thus ...