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Article
Treatment with hydroxyurea in thalassemia intermedia with paravertebral pseudotumors of extramedullary hematopoiesis
Excessive ineffective erythropoiesis in thalassemia intermedia may cause paravertebral pseudotumors of extramedullary hematopoiesis. Due to the proximity to the spinal canal, these paravertebral masses carry t...
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Article
Hemoglobinopathy York [β146 (HC3) His⇒Pro]: first report of a family history
The rare hemoglobinopathies with abnormal oxygen binding are usually characterized by erythropoietin-mediated erythrocytosis. Bare et al. first described a hemoglobinopathy with mild erythrocytosis in a 22-ye...
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Article
Epidemiological situation and treatment of patients with thalassemia major in Germany: results of the German multicenter β-thalassemia study
At present, about 300 patients in Germany suffer from thalassemia major. In 1990, a multicenter study was introduced to identify all thalassemic patients in Germany as well as to establish a uniform therapy p...
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Article
Anaemia, thrombocytopenia and coagulopathy due to occult diffuse infantile haemangiomatosis of spleen and pancreas
Diffuse infantile haemangiomatosis of the spleen is a very rare lesion. Large haemangiomas may cause trap** of platelets and coagulation disorders known as Kasabach-Merrit syndrome. We here report the case ...
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Chapter
The application of markers for embryogenesis and organogenesis in coconut propagation
Coconut palms (Cocos nucifera, L.) are affected by several pests and pathogens, ranging from viroids, viruses, phytoplasmas, bacteria, fungi and insects. For some of the biotic stresses, no therapy exists, as is ...
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Article
Cardiac and extracardiac complications in infants of diabetic mothers and their relation to parameters of carbohydrate metabolism
Despite the current improvement of diabetes care in pregnancy, neonatal complications are still more frequent than in the general population. Even in fetuses of well controlled diabetic mothers, myocardial hy...
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Article
Silastic catheters for home antibiotic therapy in patients with cystic fibrosis
Repeated 14-day courses of intravenous antibiotic therapy for patients with cystic fibrosis (CF), who have been colonized with Pseudomonas aeruginosa (PA), is one currently accepted treatment. Conventional intra...
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Chapter
Side-effects of the insect growth regulator triflumuron on spiders
Laboratory bioassays and small-scale field trials were conducted to study side-effects of the insect growth regulator triflumuron (TFM) on different spider species from Europe, Mauritania and Madagascar. Vario...
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Article
Thalassemia intermedia: compound heterozygous β∘/β+-thalassemia and co-inherited heterozygous α+-thalassemia
The relative excess of α- over β-globin chains in the erythroid precursors is the chief pathophysiological factor of homozygous β-thalassemia. The clinical picture is usually characterized by a transfusion-dep...
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Article
Book reviews
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Chapter
Therapeutic Aspects of Fanconi Anemia
Fanconi anemia (FA) is an autosomal recessive disorder defined by chromosomal instability, delayed-onset marrow failure, increased risk of neoplasia, and a variety of constitutional abnormalities and congenita...
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Article
Haemoglobin freiburg: direct detection by synthetic oligonucleotide probes
The molecular defect leading to Haemoglobin (Hb) Freiburg has been analysed using synthetic oligonucleotides. Oligonucleotide probes 19 residues and 16 residues long, corresponding to the normal and mutant β-g...
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Article
Hemoglobin M Iwate is caused by a C→T transition in codon 87 of the human α1-globin gene
DNA restriction, molecular cloning, and sequencing methods have been used to characterize the mutation leading to the methemoglobinemia HbM Iwate. It could be demonstrated that the HbM Iwate defect is caused b...
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Article
Haemoglobin D-β-thalassaemia in a German family
This report concerns a young woman, whose stained blood films revealed a hypochromic and microcytic red cell morphology. It could be shown by haemoglobin analysis that this atypical blood film was due to a dou...
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Article
IgG therapy in systemic lupus erythematosus
Two paediatric patients with systemic lupus erythematosus were treated with immunoglobulin G (IgG). In the first case treatment resulted in regression of the most acute symptoms and a long remission was achiev...
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Article
Knochenmarktransplantation bei Panmyelopathie, akuter Leukämie und chronisch myeloischer Leukämie: Ergebnisse der „Ulmer Transplantationsgruppe“
From 1972–1983 53 patients underwent bone marrow transplantation. The median age was 18 years (3–41). 27 patients suffered from severe aplastic anaemia, 22 patients had acute leukaemia and 4 patients had chron...
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Article
Hemoglobin Köln: Analysis of linkage relationships between the mutant gene and polymorphic restriction sites in the β-globin gene cluster
Nuclear DNA has been analyzed by means of restriction endonuclease map** procedure to identify chromosomes that carry mutant Hb Köln β-globin genes in a family with individuals heterozygous for this disease....
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Article
Therapy of acute lymphocytic leukemia in childhood with intermediate dose methotrexate and CNS irradiation
One hundred and eight children with acute lymphocytic leukemia (ALL) were admitted to a prospective therapeutic regime. Remission induction was achieved in 94% of the cases with vincristine, L-asparaginase, ad...
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Article
Sickle cell-β+-thalassaemia: A haematological and clinical study in Liberia
Clinical and haematological features of 20 patients of several Liberian ethnic groups with sickle cell-β+-thalassaemia are reported. Haemoglobin analysis showed increased Hb A2 values, high Hb A levels (median 25...
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Chapter and Conference Paper
Hämatologie/Onkologie
Die intraerythrozytäre Ferritinkonzentration ist zusätzlich zur Serum- bzw. Plasmaferritin-konzentration [9] für die Beurteilung des Eisenhaushalts geeignet [3]. Bei latentem Eisenmangel ist die Ferritinkonzen...
