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124 Result(s)
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Article
Thalassemia intermedia: compound heterozygous β∘/β+-thalassemia and co-inherited heterozygous α+-thalassemia
The relative excess of α- over β-globin chains in the erythroid precursors is the chief pathophysiological factor of homozygous β-thalassemia. The clinical picture is usually characterized by a transfusion-dep...
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The spectrum of CFTR mutations in south-west German cystic fibrosis patients
The cystic fibrosis transmembrane conductance regulator (CFTR) gene of 110 cystic fibrosis (CF) patients from the south-west of Germany was screened for 12 different mutations. This analysis resulted in an ide...
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Book reviews
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Buchbesprechung
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Chapter and Conference Paper
Allogeneic Bone Marrow Transplantation in Childhood Leukemia: Results and Strategies in the Federal Republic of Germany
The treatment of acute leukemias in child-hood has been very successful in the Federal Republic of Germany. Multicenter trials for both, acute lymphoblastic leukemia (ALL) and acute nonlymphoblastic leukemia (...
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HLA-haploidentical bone marrow transplantation in three infants with adenosine deaminase deficiency: Stable immunological reconstitution and reversal of skeletal abnormalities
Three infants with severe combined immunodeficiency and adenosine deaminase (ADA) deficiency were treated by T-cell depleted bone marrow transplantation (BMT), using human leukocyte antigen (HLA)-haploidentica...
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Undetectable IgG4 in immunoprecipitation: association with repeated infections in children?
A total of 210 patients with repeated infections were screened for IgG4 deficiency. In 30 patients (14%) IgG4 was undetectable by radial immunodiffusion (<30 mg/l). Of these patients 17 (57%) were less than 2 ...
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Book reviews
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Chapter and Conference Paper
Bone Marrow Transplantation in Childhood Leukemia in West Germany
About 10 years ago allogeneic bone marrow transplantation (BMT) became established in West Germany as a therapeutic method for hematological malignancies. Between 1975 and April 1984, more than 300 patients we...
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Chapter and Conference Paper
Immunoglobulin and T Cell Receptor Gene Rearrangements in Acute Leukemias
Acute leukemias are commonly classified on the basis of morphologic, cytochemical and immunologic criteria. Immunologic techniques, particularly surface antigen analysis using monoclonal antibodies, have relat...
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Severe combined immunodeficiency: treatment by bone marrow transplantation in 15 infants using HLA-haploidentical donors
In 15 infants with severe combined immunodeficiency (SCID), immunological reconstitution was attempted by bone marrow transplantation (BMT) from HLA-haploidentical parents. To prevent graft versus host disease...
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Book reviews
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Chapter
T Cell Depletion of Marrow for the Prevention of Graft Versus Host Disease
Selective depletion of T cells from marrow grafts is an attractive approach to reduce the incidence and severity of GvHD. Recent studies in man clearly indicate that this approach is valid, opening the way to ...