24 Result(s)

Article

A proposal for using benefit-risk methods to improve the prominence of adverse event results when reporting trials

Adverse events suffer from poor reporting within randomised controlled trials, despite them being crucial to the evaluation of a treatment. A recent update to the CONSORT harms checklist aims to improve report...

Nikki Totton, Ed Waddingham, Ruth Owen, Steven Julious, Dyfrig Hughes… in Trials (2024)

Article

Correction: Mechanistically informed non-invasive peripheral nerve stimulation for peripheral neuropathic pain: a randomised double-blind sham-controlled trial

Selina Johnson, Anne Marshall, Dyfrig Hughes… in Journal of Translational Medicine (2023)

Article

Extended-release pharmacotherapy for opioid use disorder (EXPO): protocol for an open-label randomised controlled trial of the effectiveness and cost-effectiveness of injectable buprenorphine versus sublingual tablet buprenorphine and oral liquid methadone

Sublingual tablet buprenorphine (BUP-SL) and oral liquid methadone (MET) are the daily, standard-of-care (SOC) opioid agonist treatment medications for opioid use disorder (OUD). A sizable proportion of the OU...

John Marsden, Mike Kelleher, Zoë Hoare, Dyfrig Hughes, Jatinder Bisla… in Trials (2022)

Article

Mechanistically informed non-invasive peripheral nerve stimulation for peripheral neuropathic pain: a randomised double-blind sham-controlled trial

Induction of long-term synaptic depression (LTD) is proposed as a treatment mechanism for chronic pain but remains untested in clinical populations. Two interlinked studies; (1) A patient-assessor blinded, ran...

Selina Johnson, Anne Marshall, Dyfrig Hughes… in Journal of Translational Medicine (2021)

Article

Utilising benefit-risk assessments within clinical trials—a protocol for the BRAINS project

Depending on the treatment to be investigated, a clinical trial could be designed to assess objectives of superiority, equivalence or non-inferiority. The design of the study is affected by many different elem...

Nikki Totton, Steven Julious, Dyfrig Hughes, Jonathan Cook, Katie Biggs… in Trials (2021)

Article

Quantitative Evidence Synthesis Methods for the Assessment of the Effectiveness of Treatment Sequences for Clinical and Economic Decision Making: A Review and Taxonomy of Simplifying Assumptions

Sequential use of alternative treatments for chronic conditions represents a complex intervention pathway; previous treatment and patient characteristics affect both the choice and effectiveness of subsequent ...

Ruth A. Lewis, Dyfrig Hughes, Alex J. Sutton, Clare Wilkinson in PharmacoEconomics (2021)

Article

CARer-ADministration of as-needed subcutaneous medication for breakthrough symptoms in homebased dying patients (CARiAD): study protocol for a UK-based open randomised pilot trial

While the majority of seriously ill people wish to die at home, only half achieve this. The likelihood of someone dying at home often depends on the availability of able and willing lay carers to support them.

Marlise Poolman, Jessica Roberts, Anthony Byrne, Paul Perkins, Zoe Hoare… in Trials (2019)

Article

Core Health Outcomes In Childhood Epilepsy (CHOICE): protocol for the selection of a core outcome set

There is increasing recognition that establishing a core set of outcomes to be evaluated and reported in trials of interventions for particular conditions will improve the usefulness of health research. There ...

Christopher Morris, Colin Dunkley, Frances M. Gibbon, Janet Currier… in Trials (2017)

Article

A randomised, patient-assessor blinded, sham-controlled trial of external non-invasive peripheral nerve stimulation for chronic neuropathic pain following peripheral nerve injury (EN-PENS trial): study protocol for a randomised controlled trial

Eight percent of people in the UK are estimated to have persistent (chronic) neuropathic pain, and for many there is no effective treatment. Medications are the most common first-line treatment but often have ...

Selina Johnson, Roberta Richey, Emily Holmes, Dyfrig Hughes, Andreas Goebel in Trials (2016)

Article

Opportunity costs and local health service spending decisions: a qualitative study from Wales

All health care systems face the need to find the resources to meet new demands such as a new, cost-increasing health technology. In England and Wales, when a health technology is recommended by the National I...

Sarah Karlsberg Schaffer, Jon Sussex, Dyfrig Hughes… in BMC Health Services Research (2016)

Article

Identification of items for a standardised resource-use measure: review of current instruments

Joanna Thorn, Colin Ridyard, Ruth Riley, Sara Brookes, Dyfrig Hughes… in Trials (2015)

Article

The trials and tribulations of accessing data from routine sources

Graham Powell, Tony Marson, Dyfrig Hughes, Paula Williamson, Catrin Tudur-Smith in Trials (2015)

Article

The ROAM/EORTC-1308 trial: Radiation versus Observation following surgical resection of Atypical Meningioma: study protocol for a randomised controlled trial

Atypical meningiomas are an intermediate grade brain tumour with a recurrence rate of 39–58 %. It is not known whether early adjuvant radiotherapy reduces the risk of tumour recurrence and whether the potentia...

Michael D. Jenkinson, Mohsen Javadpour, Brian J. Haylock, Bridget Young… in Trials (2015)

Article

Study protocol for a randomised controlled trial of insulin delivery by continuous subcutaneous infusion compared to multiple daily injections

Intensive insulin therapy with continuous subcutaneous insulin infusion (CSII) devices or multiple daily injections (MDI) reduces the risk of long-term vascular complications of type I diabetes (TID). Both tre...

Jo Blair, John W Gregory, Dyfrig Hughes, Colin H Ridyard, Carrol Gamble… in Trials (2015)

Article

A randomised controlled trial of the clinical effectiveness, safety and cost-effectiveness of adalimumab in combination with methotrexate for the treatment of juvenile idiopathic arthritis associated uveitis (SYCAMORE Trial)

Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in children. Children with JIA are at risk of inflammation of the uvea in the eye (uveitis). Overall, 20% to 25% of paediatric uveitis i...

Athimalaipet V Ramanan, Andrew D Dick, Diana Benton… in Trials (2014)

Article

The British antibiotic and silver-impregnated catheters for ventriculoperitoneal shunts multi-centre randomised controlled trial (the BASICS trial): study protocol

Insertion of a ventriculoperitoneal shunt (VPS) for the treatment of hydrocephalus is one of the most common neurosurgical procedures in the UK, but failures caused by infection occur in approximately 8% of pr...

Michael D Jenkinson, Carrol Gamble, John C Hartley, Helen Hickey, Dyfrig Hughes… in Trials (2014)

Article

Using discrete choice experiments to define patient preferences for outcomes in trials

Emily Fargher, Dyfrig Hughes, Adele Ring, Ann Jacoby, Margaret Rawnsley… in Trials (2013)

Article

Review of the use of resource use instruments based on patient recall in relation to other methods of resource use estimation

Colin Ridyard, Dyfrig Hughes in Trials (2013)