6 Result(s)
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Article
Autoimmunity in Down’s syndrome via cytokines, CD4 T cells and CD11c+ B cells
Down’s syndrome (DS) presents with a constellation of cardiac, neurocognitive and growth impairments. Individuals with DS are also prone to severe infections and autoimmunity including thyroiditis, type 1 diab...
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Article
Open AccessDownregulation of exhausted cytotoxic T cells in gene expression networks of multisystem inflammatory syndrome in children
Multisystem inflammatory syndrome in children (MIS-C) presents with fever, inflammation and pathology of multiple organs in individuals under 21 years of age in the weeks following severe acute respiratory syn...
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Article
Open AccessAn ACE2 Triple Decoy that neutralizes SARS-CoV-2 shows enhanced affinity for virus variants
The SARS-CoV-2 variants replacing the first wave strain pose an increased threat by their potential ability to escape pre-existing humoral protection. An angiotensin converting enzyme 2 (ACE2) decoy that compe...
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Article
Open AccessISG15 deficiency and increased viral resistance in humans but not mice
ISG15 is an interferon (IFN)-α/β-induced ubiquitin-like protein. It exists as a free molecule, intracellularly and extracellularly, and conjugated to target proteins. Studies in mice have demonstrated a role f...
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Article
Erratum: Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation
Nature 517, 89–93 (2015); doi:10.1038/nature13801 In this Letter, author J.-L.C. was inadvertently missing one of their affiliations; they should also have been associated with affiliation number 2 (St. Giles ...
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Article
Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation
ISG15 deficiency in humans leads to a failure to maintain adequate levels of USP18, triggering an increase in type I interferon production and signalling, and promoting auto-inflammatory disease.
