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Open AccessEffects of adjuvants in a rabies-vectored Ebola virus vaccine on protection from surrogate challenge
Ebola virus is the primary contributor to the global threat of filovirus severe hemorrhagic fever, and Ebola virus disease has a case fatality rate of 50–90%. An inactivated, bivalent filovirus/rabies virus va...
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Glimpses into the Past: New World Contributions Towards Understanding the Basic Etiology, Pathobiology and Treatment of Rabies
Historical reports of rabies first appeared during the 1700s in colonial descriptions from throughout the Americas, although the disease was present much earlier. Until the 1900s, European beliefs and enlighte...
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Article
Open AccessInactivated rabies-vectored SARS-CoV-2 vaccine provides long-term immune response unaffected by vector immunity
The objective of this study is to further analyze recombinant rabies virus-vectored SARS-CoV-2 vaccine, CORAVAX, as an effective COVID-19 vaccine strategy. CORAVAX has proven immunogenic and protective against...
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Article
Open AccessMeasles-based Zika vaccine induces long-term immunity and requires NS1 antibodies to protect the female reproductive tract
Zika virus (ZIKV) can cause devastating effects in the unborn fetus of pregnant women. To develop a candidate vaccine that can protect human fetuses, we generated a panel of live measles vaccine (MV) vectors e...
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Open AccessA single dose of replication-competent VSV-vectored vaccine expressing SARS-CoV-2 S1 protects against virus replication in a hamster model of severe COVID-19
The development of effective countermeasures against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the agent responsible for the COVID-19 pandemic, is a priority. We designed and produced ConVa...
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Open AccessRabies virus-based COVID-19 vaccine CORAVAX™ induces high levels of neutralizing antibodies against SARS-CoV-2
The recently emerged coronavirus SARS-CoV-2, the causative agent of COVID-19, is rapidly spreading in the world. The exponentially expanding threat of SARS-CoV-2 to global health highlights the urgent need for...
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Open AccessPublisher Correction: Rabies-based vaccine induces potent immune responses against Nipah virus
In the original published version of this Article, the figure legends were attached to the wrong figures. The legend for Fig. 2 was moved to Fig. 4, the legend for Fig. 3 was moved to Fig. 2, and the legend fo...
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Article
Open AccessRabies-based vaccine induces potent immune responses against Nipah virus
Nipah Virus (NiV) is a re-emerging zoonotic pathogen in the genus Henipavirus of the Paramyxoviridae family of viruses. NiV is endemic to Bangladesh and Malaysia and is highly fatal to both livestock and humans (...
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Open AccessThe Final (Oral Ebola) Vaccine Trial on Captive Chimpanzees?
Could new oral vaccine technologies protect endangered wildlife against a rising tide of infectious disease? We used captive chimpanzees to test oral delivery of a rabies virus (RABV) vectored vaccine against ...