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Article
Ionic liquid promoted preparation of 4H-thiopyran and pyrimidine nucleoside-thiopyran hybrids through one-pot multi-component reaction of thioamide
One-pot multi-component reactions of aldehydes, cyanothioacetamide and malononitrile promoted by ionic liquid proved to be an efficient way for the synthesis of thiopyran derivatives. Without any added catalys...
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Article
Building the sequence map of the human pan-genome
Here we integrate the de novo assembly of an Asian and an African genome with the NCBI reference human genome, as a step toward constructing the human pan-genome. We identified ∼5 Mb of novel sequences not presen...
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Article
Ionic liquid-promoted multi-component reaction: novel and efficient preparation of pyrazolo[3,4-b]pyridinone, pyrazolo[3,4-b]-quinolinone and their hybrids with pyrimidine nucleoside
The utilization of an ionic liquid, [bmim][BF4] as both reaction medium and promoter for a multi-component reaction of aldehyde (1) and 5-amino-3-methyl-1-phenylpyrazole (2) with Meldrum acid (3) or dimedone (5) ...
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Article
Open AccessA human gut microbial gene catalogue established by metagenomic sequencing
To understand the impact of gut microbes on human health and well-being it is crucial to assess their genetic potential. Here we describe the Illumina-based metagenomic sequencing, assembly and characterizatio...
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Article
Time course of heme oxygenase-1 and oxidative stress after experimental intracerebral hemorrhage
Heme oxygenase-1 (HO-1), the rate-limiting enzyme for heme catabolism and iron production, its role in intracerebral hemorrhage (ICH) is controversial. The study was to investigate correlations between brain o...
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Chapter
Musical Intelligence Analysis
Based on the temperament and physical properties of melody, we exploit splines, Gaussian function and trigonometric functions to construct two sets of stable bases and give the proof of stability. For both con...
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Chapter and Conference Paper
The Echo Simulation of Laser Sonar Using the Random Waves Model
The laser sonar is a method of detecting underwater objects by using non-touch measure, also is a research focus recently. The laser’s echo is easily affected by the rough sea surface which is aroused by the s...
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Article
Open AccessInterlayer catalytic exfoliation realizing scalable production of large-size pristine few-layer graphene
Mass production of reduced graphene oxide and graphene nanoplatelets has recently been achieved. However, a great challenge still remains in realizing large-quantity and high-quality production of large-size t...
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Article
Downregulation of miR-383 promotes glioma cell invasion by targeting insulin-like growth factor 1 receptor
Invasiveness is a major clinical feature of glioma, an aggressive brain tumor with poor prognosis. Although there is emerging evidence that some microRNAs are involved in the glioma cell invasion process, it r...
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Article
Open AccessShiga toxin-producing Escherichia coli O104:H4: An emerging important pathogen in food safety
In 2011, Shiga toxin-producing Escherichia coli O104:H4 resulted in a large outbreak of bloody diarrhea and hemolytic uremic syndrome (HUS) in Germany and 15 other countries in Europe and North America. This even...
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Article
Genome sequencing of 161 Mycobacterium tuberculosis isolates from China identifies genes and intergenic regions associated with drug resistance
Lijun Bi and colleagues report sequencing of 161 tuberculosis strains from China, including 44 drug-sensitive, 94 MDR and 23 XDR isolates. They identify 72 new genes and 28 new intergenic regions significantly...
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Article
Open AccessEndocrine complications in patients with thalassaemia major
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Article
Open AccessGenomic characterization of a Helicobacter pylori isolate from a patient with gastric cancer in China
Helicobacter pylori is well known for its relationship with the occurrence of several severe gastric diseases. The mechanisms of pathogenesis triggered by H. pylori are less well known. In this study, we report t...
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Article
Improved genetic algorithm with two-level approximation for truss topology optimization
Truss topology optimization using Genetic Algorithms (GAs) usually requires large computational cost, especially for large-scale problems. To decrease the structural analyses, a GA with a Two-level Approximati...
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Article
Open AccessImpact of maternal dietary fat supplementation during gestation upon skeletal muscle in neonatal pigs
Maternal diet during pregnancy can modulate skeletal muscle development of the offspring. Previous studies in pigs have indicated that a fat supplemented diet during pregnancy can improve piglet outcome, howev...
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Article
Multiple sulfur and oxygen isotope compositions in Bei**g aerosol
Multiple sulfur isotopes (32S, 33S, 34S, 36S) and oxygen isotopes (16O, 18O) in Bei**g aerosols were measured with MAT-253 isotope mass spectrometer. The δ 34S values of Bei**g aerosol samples r...
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Article
Open AccessDynamic control of light emission faster than the lifetime limit using VO2 phase-change
Modulation is a cornerstone of optical communication, and as such, governs the overall speed of data transmission. Currently, the two main strategies for modulating light are direct modulation of the excited e...
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Article
Open AccessNanoscale optical interferometry with incoherent light
Optical interferometry has empowered an impressive variety of biosensing and medical imaging techniques. A widely held assumption is that devices based on optical interferometry require coherent light to gener...
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Article
Open AccessMobility and Muscle Strength Together are More Strongly Correlated with Falls in Suburb-Dwelling Older Chinese
Falls are common in older adults and result in adverse outcomes. Impaired mobility and poor muscle strength have been consistently identified as the main contributors to falls. We choose three easy-to-perform ...
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Article
Open AccessDysfunctional gut microbiota and relative co-abundance network in infantile eczema
Infantile eczema is an immunological disease that is characterized by itchy and dry skin. Recent studies have suggested that gut microbiota (GM) plays a role in the development and progression of eczema. To fu...
