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Article
Open AccessIntein-mediated temperature control for complete biosynthesis of sanguinarine and its halogenated derivatives in yeast
While sanguinarine has gained recognition for antimicrobial and antineoplastic activities, its complex conjugated structure and low abundance in plants impede broad applications. Here, we demonstrate the compl...
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Article
A transformer-based UAV instance segmentation model TF-YOLOv7
In a dense target scenario in a real city, how to efficiently achieve the labeling of different targets and overcome the problem of mutual occlusion caused by the dense targets in the process becomes the key p...
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Article
Open AccessAutomated thorax disease diagnosis using multi-branch residual attention network
Chest X-ray (CXR) is an extensively utilized radiological modality for supporting the diagnosis of chest diseases. However, existing research approaches suffer from limitations in effectively integrating multi...
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Article
Observation on the tilt and decentration of multifocal intraocular lens with optic capture in Berger space for pediatric cataract
This study aimed to observe the tilt and decentration of multifocal intraocular lens (IOL) with optic capture in Berger space within 2 years after pediatric cataract surgery.
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Article
A family of linearly weighted- \(\theta \) compact ADI schemes for sine-Gordon equations in high dimensions
This paper proposes a family of weighted- \(\theta \) θ high-order ADI schemes for sine-Gord...
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Article
Stenotrophomonas maltophilia Isolated from the Gut Symbiotic Community of the Plastic-Eating Tenebrio molitor
Polyvinyl chloride (PVC) waste is a major environmental challenge. In this study, we found that a PVC-eating insect, Tenebrio molitor, could survive by consuming PVC as a dietary supplement. To understand the gut...
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Article
Therapeutic effect of a new implantation method of rotationally asymmetric multifocal intraocular lenses on visual quality
To assess the visual quality after implantation of a rotationally asymmetric multifocal intraocular lens (IOL) using a new method according to the angle kappa.
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Article
Optimal Error Estimates of SAV Crank–Nicolson Finite Element Method for the Coupled Nonlinear Schrödinger Equation
In this paper, we reformulate the coupled nonlinear Schrödinger (CNLS) equation by using the scalar auxiliary variable (SAV) approach and solve the resulting system by using Crank-Nicolson finite element metho...
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Article
Vehicle Platoon Tracking Control Based on Adaptive Neural Network Algorithm
To improve the tracking efficiency of the platoon during driving and ensure the spacing safety between vehicles, a platoon tracking control strategy based on the adaptive neural network algorithm is developed....
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Article
Open AccessTranscriptional variation in Babesia gibsoni (Wuhan isolate) between in vivo and in vitro cultures in blood stage
Babesia gibsoni, the causative agent of canine babesiosis, belongs to the phylum Apicomplexa. The development of in vitro culture technology has driven research progress in various kinds of omics studies, includi...
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Article
Open AccessDevelopment of a Pichia pastoris cell factory for efficient production of germacrene A: a precursor of β-elemene
β-Elemene, an active ingredient found in medicinal plants like turmeric and zedoary, is a sesquiterpene compound with antitumor activity against various cancers. However, its current mode of production through...
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Article
Hybrid rice row detection at the pollination stage based on vanishing point and line-scanning method
Hybrid rice row detection at the pollination stage is critical for the automation of in-field pollination agricultural vehicles. The parental crops of hybrid rice are planted at intervals in seed production fi...
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Article
Open AccessVerification of a clinical decision support system for the diagnosis of headache disorders based on patient–computer interactions: a multi-center study
Although headache disorders are common, the current diagnostic approach is unsatisfactory. Previously, we designed a guideline-based clinical decision support system (CDSS 1.0) for diagnosing headache disorder...
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Article
Open AccessThe association between serum uric acid and cognitive performance in patients with ischemic stroke is modified by estimated glomerular filtration rate
The relationship between serum uric acid (SUA) and poor cognitive performance in patients with ischemic stroke is unclear. We hypothesized that the severity of renal function mediates the association between S...
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Article
Biosynthesis of catharanthine in engineered Pichia pastoris
Catharanthine can be coupled with vindoline to synthesize vinblastine and vincristine, which have been used clinically as potent anticancer drugs. However, the structural complexity and low abundance in nature...
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Article
Open AccessPSAT1 positively regulates the osteogenic lineage differentiation of periodontal ligament stem cells through the ATF4/PSAT1/Akt/GSK3β/β-catenin axis
Periodontal ligament stem cells (PDLSCs) are important seed cells for tissue engineering to realize the regeneration of alveolar bone. Understanding the gene regulatory mechanisms of osteogenic lineage differe...
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Article
Non-stationary modeling of wet-season precipitation over the Inner Mongolia section of the Yellow River basin
Climate system anomalies and intensified human disturbances have different impacts on the hydrological cycle at different scales, chiefly leading to prominent spatio-temporal heterogeneities in precipitation d...
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Article
Open AccessTension of plus-end tracking protein Clip170 confers directionality and aggressiveness during breast cancer migration
The microtubule (MT) plus-end binding protein Clip170 is associated closely with breast cancer invasion and migration. In this study, Clip170 tension observed by a newly designed cpstFRET tension probe was sug...
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Article
Open AccessEnrichment and proteomic identification of Cryptosporidium parvum oocyst wall
Cryptosporidium parvum is a zoonotic parasitic protozoan that can infect a variety of animals and humans and is transmitted between hosts via oocysts. The oocyst wall provides strong protection against hostile en...
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Article
Unconditionally optimal convergence of an energy-conserving and linearly implicit scheme for nonlinear wave equations
In this paper, we present and analyze an energy-conserving and linearly implicit scheme for solving the nonlinear wave equations. Optimal error estimates in time and superconvergent error estimates in space ar...
