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Article
Integration of modern science into herbal medicine: application of pharmacokinetic-pharmacodynamic modeling in understanding nonclinical study of Cinnamomum cassia extract.
CKD-495 is a tablet form of Cinnamomum cassia Presl extract (CCE), which is a commonly used herb in traditional medicine that exhibits several pharmacological effects including anti-gastritis activities. This stu...
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Article
Multicompartmental pharmacokinetic evaluation of enavogliflozin eye drop formulation: Understanding its distribution to posterior segments
Treating posterior segment diseases presents significant challenges because of the intricate anatomical and physiological barriers within the eye that limit drug penetration. Enavogliflozin eye drops (DWRX2008...
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Article
Physiologically-based pharmacokinetic model for evaluating gender-specific exposures of N-nitrosodimethylamine (NDMA)
N-nitrosodimethylamine (NDMA) is classified as a human carcinogen and could be produced by both natural and industrial processes. Although its toxicity and histopathology have been well-studied in animal specie.....
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Article
Open AccessAntinociceptive effect of intermittent fasting via the orexin pathway on formalin-induced acute pain in mice
It has been suggested that stress responses induced by fasting have analgesic effects on nociception by elevating the levels of stress-related hormones, while there is limited understanding of pain control mec...
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Chapter and Conference Paper
A Study on the Construction of Crime Prevention System Using the Hadoop Model of Big Data- with Focus on Utilizing Big Data and CPTED Technology in Gimcheon-Si -
The crime rate in Gimcheon through the analysis of big data in 2020 was 3933 cases in Gimcheon City in 2019, up 5.2% from 3740 cases in the previous year. If big data managed by the police is used as informati...
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Article
Strategies for develo** Alzheimer’s disease treatments: application of population pharmacokinetic and pharmacodynamic models
As the number of Alzheimer's disease (AD) patients steadily increases, many pharmaceutical industries and researchers are making efforts and investments in develo** AD treatments. However, numerous AD new dr...
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Article
Open AccessAntiallodynic effects of KDS2010, a novel MAO-B inhibitor, via ROS-GABA inhibitory transmission in a paclitaxel-induced tactile hypersensitivity model
Monoamine oxidase (MAO) inhibitors have been investigated for the treatment of neuropathic pain. Here, we assessed the antiallodynic effects of a novel MAO-B inhibitor, KDS2010, on paclitaxel (PTX)-induced mec...
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Article
Population pharmacokinetic modeling and simulation of choline in healthy Korean subjects after oral administration of choline alfoscerate
This study aimed to investigate clinical pharmacokinetics (PKs) of choline after oral administration of choline alfoscerate capsule and newly developed syrup formulation using population pharmacokinetic modeli...
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Article
In vitro and in vivo evaluations of a 3-month sustained-release microsphere depot formulation of leuprolide acetate
The aim of this work was to evaluate a new polylactic acid microsphere depot formulation (Leuprolide Depot 3 M) prepared by a water-in-oil-in-water emulsion/solvent evaporation method.
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Article
Open AccessPlasma fetal bile acids 7α-hydroxy-3-oxochol-4-en-24-oic acid and 3-oxachola-4,6-dien-24-oic acid indicate severity of liver cirrhosis
Two 3-oxo-Δ4 fetal bile acids, 3-oxachola-4,6-dien-24-oic acid (1) and 7α-hydroxy-3-oxochol-4-en-24-oic acid (2), occur normally in the human fetus but remain elevated in neonates and children with severe cholest...
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Article
Gender differences in pharmacokinetics of perfluoropentanoic acid using non-linear mixed-effect modeling in rats
Perfluoroalkyl and polyfluoroalkyl substances (PFASs) have been used in various industrial applications for many years. Long-chain PFASs are ubiquitous in wildlife and are reported to have a long elimination h...
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Article
Open AccessTLR4-mediated autophagic impairment contributes to neuropathic pain in chronic constriction injury mice
Neuropathic pain is a complex, chronic pain state characterized by hyperalgesia, allodynia, and spontaneous pain. Accumulating evidence has indicated that the microglial Toll-like receptor 4 (TLR4) and autopha...
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Article
A method to reduce the complexity of conditional replenishment algorithm for hybrid 3DTV with mixed resolution
SC-MMH (Service Compatible 3DTV using Main and Mobile Hybrid) is a kind of hybrid 3DTV system where the resolutions of stereoscopic views are not identical and has become one of ATSC standards for terrestrial ...
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Article
Open AccessAntinociceptive Profile of Levo-tetrahydropalmatine in Acute and Chronic Pain Mice Models: Role of spinal sigma-1 receptor
We have recently reported that repeated systemic treatments of extract from Corydalis yanhusuo alleviate neuropathic pain and levo-tetrahydropalmatine (l-THP) is one of active components from Corydalis. We design...
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Chapter and Conference Paper
Compensation of Directional and Rotational Mismatch of Separate Stereo Cameras by Vanishing Point and Lines
The rectification of stereoscopic image is indispensable process to implement stereo vision system since the accuracy of estimated disparity strongly depends on the alignment of epipolar line. A new and simple...
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Chapter and Conference Paper
A Study on the Hierarchical Structure of Conditional Replenishment Algorithm for SC-MMH 3DTV System
CRA (Conditional Replenishment Algorithm) has been proposed to improve the visual quality of asymmetrical 3DTV where the resolutions of two views are not matched. CRA adopts variable-sized PU (Processing Unit)...
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Chapter and Conference Paper
An Innovative Platform for Person-Centric Health and Wellness Support
Modern digital technologies are paving the path to a revolutionary new concept of health and wellness care. Nowadays, many new solutions are being released and put at the reach of most consumers for promoting ...
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Chapter and Conference Paper
Multi-Focus Image Fusion by Using a Pixel-Based SML Comparison Map
The fusion of images which have different focal lengths can play important role for visual enhancement. It can also be used as a pre-processing step for various processing modules such as edge detection and fe...
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Chapter and Conference Paper
Quality Analysis of Conditional Replenishment Algorithm for Hybrid 3DTV with Mixed Resolution
The perceived visual quality of the hybrid 3DTV system of which resolutions are not matched is dominated by the higher quality one. But the mismatch may be an issue when the quality gap between two views is qu...
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Article
Structural insights into transient receptor potential vanilloid type 1 (TRPV1) from homology modeling, flexible docking, and mutational studies
The transient receptor potential vanilloid subtype 1 (TRPV1) is a non-selective cation channel composed of four monomers with six transmembrane helices (TM1–TM6). TRPV1 is found in the central and peripheral n...
