-
Article
Comparative Analysis of the Dynamic Behaviors of Steel Pedestrian Bridges with Circular Tubular Girders
The dynamic behavior of two circular tubular steel pedestrian bridges, namely an end cut-off girder bridge and a concrete-filled girder bridge, were examined in this study. The former is proposed in this study...
-
Article
Open AccessAssociation between life-style, metabolic syndrome and lower urinary tract symptoms and its impact on quality of life in men ≥ 40 years
We aimed to assess the relationship between lifestyle-related variables, metabolic syndrome, and lower urinary tract symptoms (LUTS) in men ≥ 40 years. We also assessed the impact of these variables on quality...
-
Article
Open AccessPeroxiredoxin-6 regulates p38-mediated epithelial–mesenchymal transition in HCT116 colon cancer cells
Peroxiredoxins (Prxs) are antioxidant enzymes that protect cells from oxidative stress induced by several factors. They regulate several signaling pathways, such as metabolism, immune response, and intracellul...
-
Article
Open AccessAssociation between body fat parameters and arterial stiffness
The influence of body fat on arterial stiffness remains controversial. This study was performed to investigate the associations between four different types of body fat parameters and brachial-ankle pulse wave...
-
Article
Investigation of droplets released during digestive endoscopy using a high-speed camera (with video): a pilot study
A large release of droplets is often expected around the periphery of the digestive endoscope insertion site. Therefore, a sense of alarm over infection because of droplets that may be released during digestiv...
-
Article
Isoliquiritigenin Reduces LPS-Induced Inflammation by Preventing Mitochondrial Fission in BV-2 Microglial Cells
Excessive microglial cell activation in the brain can lead to the production of various neurotoxic factors (e.g., pro-inflammatory cytokines, nitric oxide) which can, in turn, initiate neurodegenerative processes...
-
Article
A Concise Hysteretic Model of 590 N/mm2 Grade High Performance Steel Considering the Bauschinger Effect
A concise hysteretic model of 590 N/mm2 grade high performance steel SA440 which is used in Japan for building structure is proposed. First, cyclic loading tests of steel components under constant and programmed ...
-
Article
Technical feasibility of a newly designed bendable forceps for difficult endoscopic tissue samplings (with video)
Biopsies with conventional forceps beyond the operating range are difficult and cumbersome. Thus, we developed a new bendable forceps for improved access to gastrointestinal lesions and evaluated its technical...
-
Article
Open AccessRNA sequencing reveals that Prx II gene knockout can down-regulate the allograft rejection of dermal mesenchymal stem cells
In this study, we used RNA sequencing (RNA-seq) to analyze and compare bulk cell samples from wild-type (WT) dermal mesenchymal stem cells (DMSCs) (n = 3) and Prx II knockout DMSCs (n = 3). The purpose of the stu...
-
Article
Open AccessSynaptic loss and amyloid beta alterations in the rodent hippocampus induced by streptozotocin injection into the cisterna magna
To date, researchers have developed various animal models of Alzheimer’s disease (AD) to investigate its mechanisms and to identify potential therapeutic treatments. A widely recognized model that mimics the p...
-
Article
Open Access30 years revisit survey for long-term changes in the Antarctic subtidal algal assemblage
A long-term change of a subtidal macroalgal assemblage has been investigated in Maxwell Bay, King George Island (KGI) of the Antarctic coast by a revisit survey after 30 years. Field surveys were done by SCUBA...
-
Article
Open AccessAnti-inflammatory effect of hispidin on LPS induced macrophage inflammation through MAPK and JAK1/STAT3 signaling pathways
Severe inflammatory reactions caused by macrophage activation can trigger a systemic immune response. In the present study, we observed the anti-inflammatory properties of hispidin on LPS induced RAW264.7 macr...
-
Article
Peroxiredoxin 4 inhibits insulin-induced adipogenesis through regulation of ER stress in 3T3-L1 cells
Obesity was originally considered a disease endemic to developed countries but has since emerged as a global health problem. Obesity is characterized by abnormal or excessive lipid accumulation (World Health O...
-
Article
Open AccessPeroxiredoxin 5 deficiency exacerbates iron overload-induced neuronal death via ER-mediated mitochondrial fission in mouse hippocampus
Iron is an essential element for cellular functions, including those of neuronal cells. However, an imbalance of iron homeostasis, such as iron overload, has been observed in several neurodegenerative diseases...
-
Article
Open AccessZoom motion estimation for color and depth videos using depth information
In this paper, two methods of zoom motion estimation for color and depth videos by using depth information are proposed. Color and depth videos are independently estimated for zoom motion. Zoom for color video...
-
Article
Open AccessClinical significance of regional lymph node enlargement in patients with EGC within the expanded criteria for ESD
Lymph node (LN) metastasis is negligible in early gastric cancer (EGC) within expanded criteria for endoscopic submucosal dissection (ESD). However, regional lymph nodes in abdominal CT scans are sometimes enl...
-
Article
Peroxiredoxin 4 ameliorates amyloid beta oligomer-mediated apoptosis by inhibiting ER-stress in HT-22 hippocampal neuron cells
Alzheimer’s disease (AD) is a neurodegenerative disorder caused by amyloid beta oligomers (AβO), which induce cell death by triggering oxidative stress and endoplasmic reticulum (ER) stress. Oxidative stress i...
-
Article
Open AccessPeroxiredoxin II negatively regulates BMP2-induced osteoblast differentiation and bone formation via PP2A Cα-mediated Smad1/5/9 dephosphorylation
Peroxiredoxin II (Prx II), an antioxidant enzyme in the Prx family, reduces oxidative stress by decreasing the intracellular ROS levels. Osteoblast differentiation is promoted by bone morphogenetic protein 2 (...
-
Article
Open AccessA negative feedback loop between XBP1 and Fbw7 regulates cancer development
In cancer, activation of X-box binding protein (XBP1) has a critical role in tumorigenesis and cancer progression. Transcriptional regulatory mechanism of XBP1 in cancer development has been well known, howeve...
-
Chapter
Pathology and Cell-Based Therapy of Parkinson’s Disease
Parkinson’s disease (PD) comprises an age-related and the second most common disorders which is characterized by progressive motor symptoms such as bradykinesia, rigidity, akinesia, abnormal posture, and resti...
