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Article
Regulatory Framework for Drug-Device Combination Products in the United States, Europe, and Korea
Combination products (CPs) combine two or more product types such as drugs, devices, and/or biological products for increased safety and clinical effectiveness. The emergence of innovative CPs poses new challe...
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Article
Mahalanobis Distance Based Multivariate Outlier Detection to Improve Performance of Hypertension Prediction
In recent years, the incidence of hypertension diseases has increased dramatically, not only among the elderly but also among young people. In this regard, the use of machine learning methods to diagnose the c...
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Article
Novel side pose classification model of stretching gestures using three-layer LSTM
In recent years, low back pain rehabilitation exercises have been widely performed for spine-related illnesses. To facilitate rehabilitation exercises, pose-based human action recognition technique is used to ...
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Chapter and Conference Paper
OrdinalEncoder and PCA based NB Classification for Leaked Natural Gas Prediction Using IoT based Remote Monitoring System
The natural gas (NG), usually methane gas, leaks into the air; it is a big problem for air pollution and the environment. In this paper, we propose to predict gas leakage using ML methods based on the open dat...
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Article
Soshiho-tang protects LPS-induced acute liver injury by attenuating inflammatory response
Soshiho-tang (SSHT) has traditionally been used to treat gastrointestinal disorders. In this experiment, we investigated the protective effect of SSHT on inflammatory liver injury in lipopolysaccharide (LPS)-s...
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Article
Open AccessHuman placenta induces hair regrowth in chemotherapy-induced alopecia via inhibition of apoptotic factors and proliferation of hair follicles
The human placenta (HP) is a complex organ used to alleviate tiredness and promote wound healing. Previous research showed the hair growth-promoting effect of HP. However, no reports have addressed the effects...
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Article
Peroxiredoxin 4 inhibits insulin-induced adipogenesis through regulation of ER stress in 3T3-L1 cells
Obesity was originally considered a disease endemic to developed countries but has since emerged as a global health problem. Obesity is characterized by abnormal or excessive lipid accumulation (World Health O...
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Article
Towards jitter-free ultrafast electron diffraction technology
Stroboscopic visualization of nuclear or electron dynamics in atoms, molecules or solids requires ultrafast pump and probe pulses and a close to perfect synchronization between the two. We have developed a 3 M...
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Article
Implementation of hybrid P2P networking distributed web crawler using AWS for smart work news big data
Web crawlers collect and index the vast amount of data available online to gather specific types of objective data such as news that researchers or practitioners need. As big data are increasingly used in a va...
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Article
Performance analysis of the stop-and-wait automatic repeat request protocol under Markovian interruptions
The performance of an integrated packet voice/data multiplexer using a stop-and-wait (SW) automatic repeat request (ARQ) protocol is discussed. We assume that the input for the data traffic is exponentially di...
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Article
Chrysophanol, an anthraquinone from AST2017-01, possesses the anti-proliferative effect through increasing p53 protein levels in human mast cells
Natural products are well known as the source of drugs in the treatment of allergic inflammation. Chrysophanol, an anthraquinone from the AST2017-01 extract, showed a beneficial anti-inflammatory effect on act...
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Article
Performance of an Indium-sealed S-band RF Photoelectron Gun for Time-resolved Electron Diffraction Experiments
We have developed a one-and-half -cell S-band radio-frequency (RF) photoelectron gun (photogun) fed by a coaxial coupler. The RF photogun is dedicated to ultrafast-electron-diffraction experiments by generatin...
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Article
Open AccessInhibition of RANKL-stimulated osteoclast differentiation by Schisandra chinensis through down-regulation of NFATc1 and c-fos expression
Schisandra chinenesis (SC) has been reported to have ameliorative effect on osteoporosis. However, the mechanisms underlying the anti-osteoporosis activity of SC have not been clearly elucidated. In the present s...
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Article
Adaptive Spatiotemporal Feature Extraction and Dynamic Combining Methods for Selective Visual Attention System
This paper introduces a selective attention system that guides users to detect the regions of interest more effectively by adaptively selecting and using spatial and temporal features according to the input im...
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Article
Schizandra chinensis exhibits phytoestrogenic effects by regulating the activation of estrogen receptor-α and -β
To investigate the phytoestrogenic effects of Schizandra chinensis (SC) extract by regulating the activation of estrogen receptor.
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Article
The impact of social factors on excessive online game usage, moderated by online self-identity
Social interaction is the most important factor that distinguishes online games from traditional computer games. In recent years, online games have become a part of everyday life because such games provide opp...
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Article
Polygonatum stenophyllum improves menopausal obesity via regulation of lipolysis-related enzymes
Menopausal women are associated with an increase in obesity accompanying changes in the body's condition and composition. Polygonatum stenophyllum (PS) rhizome, which is a traditional herbal remedy, has been use...
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Article
Inhibitory effects of Leonurus sibiricus on weight gain after menopause in ovariectomized and high-fat diet-fed mice
Leonurus sibiricus, also called motherwort, is a well-known functional food and medicinal herb. It has been known to possess beneficial properties for women’s health, especially for aged ...
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Article
Regulation of osteoclastic and osteoblastic differentiation marker expressions in osteoblast-like saos-2 cells by Eucommia ulmoides
Bone metabolism characterized by bone resorption by osteoclasts and bone formation by osteoblasts. Imbalances of osteoclast and osteoblast occurred bone diseases, such as osteoporosis. Eucommia ulmoide, which is ...
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Article
Artemisia annua L. extract ameliorates galactose-induced cognitive impairment in mice
Our previous study showed that Artemisia annua L. extract (AAE) exerted antioxidative effect in a mouse model. Therefore, we hypothesized that AAE could also protect against oxidative stress-induced cognitive imp...
