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    Increased functional coupling of the mu opioid receptor in the anterior insula of depressed individuals

    The mu opioid receptor (MOR) is a G protein-coupled receptor that plays an essential role in reward and hedonic processes, and that has been implicated in disorders such as depression and addiction. Over the l...

    Pierre-Eric Lutz, Daniel Almeida, Dominique Filliol in Neuropsychopharmacology (2021)

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    Distinct Mu, Delta, and Kappa Opioid Receptor Mechanisms Underlie Low Sociability and Depressive-Like Behaviors During Heroin Abstinence

    Addiction is a chronic disorder involving recurring intoxication, withdrawal, and craving episodes. Esca** this vicious cycle requires maintenance of abstinence for extended periods of time and is a true cha...

    Pierre-Eric Lutz, Gulebru Ayranci, Paul Chu-Sin-Chung in Neuropsychopharmacology (2014)