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Article
Increased functional coupling of the mu opioid receptor in the anterior insula of depressed individuals
The mu opioid receptor (MOR) is a G protein-coupled receptor that plays an essential role in reward and hedonic processes, and that has been implicated in disorders such as depression and addiction. Over the l...
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Article
Distinct Mu, Delta, and Kappa Opioid Receptor Mechanisms Underlie Low Sociability and Depressive-Like Behaviors During Heroin Abstinence
Addiction is a chronic disorder involving recurring intoxication, withdrawal, and craving episodes. Esca** this vicious cycle requires maintenance of abstinence for extended periods of time and is a true cha...