79 Result(s)
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Article
Neural substrates for regulating self-grooming behavior in rodents
Grooming, as an evolutionarily conserved repetitive behavior, is common in various animals, including humans, and serves essential functions including, but not limited to, hygiene maintenance, thermoregulation...
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Article
ROS-responsive nanoparticles targeting inflamed colon for synergistic therapy of inflammatory bowel disease via barrier repair and anti-inflammation
The destruction of the intestinal barrier is likely to cause an increase in intestinal permeability and cause pathological damage. Numerous studies have demonstrated that intestinal barrier function plays an i...
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Article
Mathematical derivation and mechanism analysis of beta oscillations in a cortex-pallidum model
In this paper, we develop a new cortex-pallidum model to study the origin mechanism of Parkinson's oscillations in the cortex. In contrast to many previous models, the globus pallidus internal (GPi) and extern...
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Article
The reformation of catalyst: From a trial-and-error synthesis to rational design
The appropriate catalysts can accelerate the reaction rate and effectively boost the efficient conversion of various molecules, which is of great importance in the study of chemistry, chemical industry, energy...
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Article
PIEZO1 mechanically regulates the antitumour cytotoxicity of T lymphocytes
The killing function of cytotoxic T cells can be enhanced biochemically. Here we show that blocking the mechanical sensor PIEZO1 in T cells strengthens their traction forces and augments their cytotoxicity aga...
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Highly selective and efficient photocatalytic NO removal: Charge carrier kinetics and interface molecular process
The widespread nitrogen oxides (NOx, mainly in NO) in the atmosphere have threatened human health and ecological environment. The dilute NO (ppb) is difficult to efficiently remove via the traditional process due...
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Article
Atomically dispersed materials: Ideal catalysts in atomic era
Catalysts can accelerate the chemical reaction rate and effectively promote the molecules transformation, which is of great significance in the research of chemical industry and material science. The extreme u...
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Article
Open AccessResearch on radiotherapy related genes and prognostic target identification of rectal cancer based on multi-omics
Radiosensitivity of rectal cancer is related to the radiotherapy efficacy and prognosis of patients with rectal cancer, and the genes and molecular mechanisms related to radiosensitivity of rectal cancer have ...
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Article
Open AccessIbrutinib combination therapy for advanced gastrointestinal and genitourinary tumours: results from a phase 1b/2 study
Ibrutinib, a first-in-class inhibitor of Bruton’s tyrosine kinase, is approved for the treatment of various B-cell malignancies and chronic graft-versus-host disease. Based on encouraging preclinical data, saf...
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Article
Dietary restriction to optimize T cell immunity is an ancient survival strategy conserved in vertebrate evolution
Recent advances highlight a key role of transient fasting in optimizing immunity of human and mouse. However, it remains unknown whether this strategy is independently acquired by mammals during evolution or i...
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Article
Single-atom cobalt nanozymes promote spinal cord injury recovery by anti-oxidation and neuroprotection
Oxidative stress and inflammation are central pathophysiological processes in a traumatic spinal cord injury (SCI). Antioxidant therapies that reduce the reactive oxygen and nitrogen species (RONS) overgenerat...
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Article
Uncovering the Burden of Immune-Related Adverse Events in Immunotherapy: Insights from a Nationally Representative Sample
Immune checkpoint inhibitors have shown promising efficacy in multiple malignancies and, therefore, have been increasingly used over the past decade. Clinical data have suggested anti-cancer efficacy associate...
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Article
Open AccessGenome-wide association analyses identified novel susceptibility loci for pulmonary embolism among Han Chinese population
A large proportion of pulmonary embolism (PE) heritability remains unexplained, particularly among the East Asian (EAS) population. Our study aims to expand the genetic architecture of PE and reveal more genet...
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Article
Revealing the surface atomic arrangement of noble metal alkane dehydrogenation catalysts by a stepwise reduction-oxidation approach
Surface characterization of metal nanoparticles is a critical need in nanocatalysis for in-depth understanding of the structure-function relationships. The surface structure of nanoparticles is often different...
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Article
GAS5 attenuates the malignant progression of glioma stem-like cells by promoting E-cadherin
It has been widely reported that glioma stem-like cells (GSCs) serve a crucial role in the malignant progression of glioma. In particular, recent studies have reported that long non-coding RNAs (lncRNAs) are c...
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Article
The adjustment mechanism of the spike and wave discharges in thalamic neurons: a simulation analysis
Different from many previous theoretical studies, this paper explores the regulatory mechanism of the spike and wave discharges (SWDs) in the reticular thalamic nucleus (TRN) by a dynamic computational model. ...
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Article
Open AccessPrognostic significance of systemic immune-inflammation index in patients with nasopharyngeal carcinoma: a meta-analysis
Previous studies have investigated the prognostic value of the systemic immune-inflammation index (SII) in nasopharyngeal carcinoma (NPC). However, the results have been inconsistent. Therefore, this study aim...
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Article
Open AccessA photodynamically sensitized dendritic cell vaccine that promotes the anti-tumor effects of anti-PD-L1 monoclonal antibody in a murine model of head and neck squamous cell carcinoma
Immune checkpoint inhibitors are promising tools in combating several cancers, including head and neck squamous cell carcinoma (HNSCC). However, a substantial portion of HNSCC patients do not respond to PD-L1 ...
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Article
Open AccessAtrial myocyte-derived exosomal microRNA contributes to atrial fibrosis in atrial fibrillation
Atrial fibrosis plays a critical role in the development of atrial fibrillation (AF). Exosomes are a promising cell-free therapeutic approach for the treatment of AF. The purposes of this study were to explore...
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Article
Emerging low-nuclearity supported metal catalysts with atomic level precision for efficient heterogeneous catalysis
Supported atomically dispersed metal catalysts (ADMCs) have received enormous attention due to their high atom utilization efficiency, mass activity and excellent selectivity. Single-atom site catalysts (SACs)...
