30 Result(s)
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Article
Neural substrates for regulating self-grooming behavior in rodents
Grooming, as an evolutionarily conserved repetitive behavior, is common in various animals, including humans, and serves essential functions including, but not limited to, hygiene maintenance, thermoregulation...
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Article
Mathematical derivation and mechanism analysis of beta oscillations in a cortex-pallidum model
In this paper, we develop a new cortex-pallidum model to study the origin mechanism of Parkinson's oscillations in the cortex. In contrast to many previous models, the globus pallidus internal (GPi) and extern...
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Article
PIEZO1 mechanically regulates the antitumour cytotoxicity of T lymphocytes
The killing function of cytotoxic T cells can be enhanced biochemically. Here we show that blocking the mechanical sensor PIEZO1 in T cells strengthens their traction forces and augments their cytotoxicity aga...
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Article
Open AccessResearch on radiotherapy related genes and prognostic target identification of rectal cancer based on multi-omics
Radiosensitivity of rectal cancer is related to the radiotherapy efficacy and prognosis of patients with rectal cancer, and the genes and molecular mechanisms related to radiosensitivity of rectal cancer have ...
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Article
Open AccessIbrutinib combination therapy for advanced gastrointestinal and genitourinary tumours: results from a phase 1b/2 study
Ibrutinib, a first-in-class inhibitor of Bruton’s tyrosine kinase, is approved for the treatment of various B-cell malignancies and chronic graft-versus-host disease. Based on encouraging preclinical data, saf...
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Article
GAS5 attenuates the malignant progression of glioma stem-like cells by promoting E-cadherin
It has been widely reported that glioma stem-like cells (GSCs) serve a crucial role in the malignant progression of glioma. In particular, recent studies have reported that long non-coding RNAs (lncRNAs) are c...
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Article
The adjustment mechanism of the spike and wave discharges in thalamic neurons: a simulation analysis
Different from many previous theoretical studies, this paper explores the regulatory mechanism of the spike and wave discharges (SWDs) in the reticular thalamic nucleus (TRN) by a dynamic computational model. ...
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Open AccessA photodynamically sensitized dendritic cell vaccine that promotes the anti-tumor effects of anti-PD-L1 monoclonal antibody in a murine model of head and neck squamous cell carcinoma
Immune checkpoint inhibitors are promising tools in combating several cancers, including head and neck squamous cell carcinoma (HNSCC). However, a substantial portion of HNSCC patients do not respond to PD-L1 ...
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Article
Open AccessAtrial myocyte-derived exosomal microRNA contributes to atrial fibrosis in atrial fibrillation
Atrial fibrosis plays a critical role in the development of atrial fibrillation (AF). Exosomes are a promising cell-free therapeutic approach for the treatment of AF. The purposes of this study were to explore...
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Article
Metabolic lactate production coordinates vasculature development and progenitor behavior in the develo** mouse neocortex
Proper neural progenitor behavior in conjunction with orderly vasculature formation is fundamental to the development of the neocortex. However, the mechanisms coordinating neural progenitor behavior and vesse...
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Article
Open AccessRUNX3-mediated circDYRK1A inhibits glutamine metabolism in gastric cancer by up-regulating microRNA-889-3p-dependent FBXO4
Targeting glutamine metabolism is previously indicated as a potential and attractive strategy for gastric cancer (GC) therapy. However, the underlying mechanisms responsible for the modification of glutamine m...
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Author Correction: Dectin 1 activation on macrophages by galectin 9 promotes pancreatic carcinoma and peritumoral immune tolerance
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Article
Open AccessA novel PDX modeling strategy and its application in metabolomics study for malignant pleural mesothelioma
Malignant pleural mesothelioma (MPM) is a rare and aggressive carcinoma located in pleural cavity. Due to lack of effective diagnostic biomarkers and therapeutic targets in MPM, the prognosis is extremely poor...
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Article
The theoretical mechanism of Parkinson’s oscillation frequency bands: a computational model study
Excessive synchronous oscillation activities appear in the brain is a key pathological feature of Parkinson’s disease, the mechanism of which is still unclear. Although some previous studies indicated that ...
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Article
Open AccessIdentification of the prognostic value of ferroptosis-related gene signature in breast cancer patients
Breast cancer (BRCA) is a malignant tumor with high morbidity and mortality, which is a threat to women’s health worldwide. Ferroptosis is closely related to the occurrence and development of breast cancer. He...
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Article
Open AccessPhase 1 study of mTORC1/2 inhibitor sapanisertib (TAK-228) in advanced solid tumours, with an expansion phase in renal, endometrial or bladder cancer
This Phase 1 dose-escalation/expansion study assessed safety/tolerability of sapanisertib, an oral, highly selective inhibitor of mTORC1/mTORC2, in advanced solid tumours.
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Article
Regulation and control roles of the basal ganglia in the development of absence epileptiform activities
Absence epileptiform activities are traditionally considered to be primarily induced by abnormal interactions between the cortical and thalamic neurons, which form the thalamocortical circuit in the brain. The...
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Article
Open AccessThe association between hypoxia inducible factor 1 subunit alpha gene rs2057482 polymorphism and cancer risk: a meta-analysis
The rs2057482 polymorphism in the hypoxia inducible factor 1 subunit alpha (HIF1A) gene has been reported to be associated with a risk of several types of cancer, but this association has not yet been definitivel...
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Article
Whole-genome sequencing of 175 Mongolians uncovers population-specific genetic architecture and gene flow throughout North and East Asia
The genetic variation in Northern Asian populations is currently undersampled. To address this, we generated a new genetic variation reference panel by whole-genome sequencing of 175 ethnic Mongolians, represe...
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Open AccessSolitary pancreatic metastasis of extremity myxoid liposarcoma: a case report and literature review
Myxoid liposarcoma has a distinct migration aptitude; however, pancreatic metastasis is rare.
