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  1. No Access

    Article

    A novel target for combination immunotherapy in pancreatic cancer: IL-1β mediates immunosuppression in the tumour microenvironment

    Immune checkpoint blockade (ICB) has demonstrated efficacy in multiple cancers, offering the potential of long-term disease control not achievable with cytotoxic or targeted therapies. However, the field has n...

    Rafael Winograd, Diane M. Simeone, Dafna Bar-Sagi in British Journal of Cancer (2021)

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    Article

    ATDC mediates a TP63-regulated basal cancer invasive program

    Basal subtype cancers are deadly malignancies but the molecular events driving tumor lethality are not completely understood. Ataxia-telangiectasia group D complementing gene (ATDC, also known as TRIM29), is high...

    Phillip L. Palmbos, Yin Wang, Armand Bankhead III, Alan J. Kelleher… in Oncogene (2019)

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    Reference Work Entry In depth

    Pancreatic Cancer Stem Cells

    Cancer stem cells (CSCs) are a distinct subpopulation of cells within a tumor that are capable of self-renewal and producing differentiated progeny. These cells appear to be more resilient to treatment than bu...

    Mackenzie Goodwin, Ethan V. Abel, Vinee Purohit, Diane M. Simeone in Pancreatic Cancer (2018)

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    Reference Work Entry In depth

    Pancreatic Cancer Stem Cells

    Diane M. Simeone in Encyclopedia of Cancer (2017)

  5. No Access

    Article

    A phase I trial of cabozantinib and gemcitabine in advanced pancreatic cancer

    Background Cabozantinib and gemcitabine improve tumor control in pancreatic ductal adenocarcinoma (PDAC) in preclinical models through c-Met inhibition. We sought to determine the maximum...

    David B. Zhen, Kent A. Griffith, Joshua M. Ruch… in Investigational New Drugs (2016)

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    Living Reference Work Entry In depth

    Pancreatic Cancer Stem Cells

    Cancer stem cells (CSCs) are a distinct subpopulation of cells within a tumor that are capable of self-renewal and producing differentiated progeny. These cells appear to be more resilient to treatment than bu...

    Mackenzie Goodwin, Ethan V. Abel, Vinee Purohit, Diane M. Simeone in Pancreatic Cancer

  7. No Access

    Living Reference Work Entry In depth

    Pancreatic Cancer Stem Cells

    Diane M. Simeone in Encyclopedia of Cancer

  8. No Access

    Reference Work Entry In depth

    Pancreas Cancer Stem Cells

    Cheong J. Lee, Diane M. Simeone, David G. Heidt in Encyclopedia of Cancer (2011)

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    Reference Work Entry In depth

    Pancreatic Cancer Stem Cells

    The concept of cancer stem cells was first proposed 150 years ago and recent studies have demonstrated the existence of cancer stem cells that have the exclusive capacity for tumor initiation and propagation. ...

    Chenwei Li, Diane M. Simeone in Pancreatic Cancer (2010)

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    Protocol

    All-Liquid Separations, Protein Microarrays, and Mass Spectrometry to Interrogate Serum Proteomes: An Application to Serum Glycoproteomics

    Disease-related changes in serum proteins are reasonable targets for early detection particularly due to the noninvasive approach in obtaining samples. Glycoproteins specifically have been implicated in a vari...

    Tasneem H. Patwa, Yinghua Qiu, Jia Zhao, Diane M. Simeone… in Tumor Biomarker Discovery (2009)

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    Protocol

    Identification of Human Pancreatic Cancer Stem Cells

    Emerging evidence suggests that malignant tumors are composed of a small subset of distinct cancer cells, termed “cancer stem cells” (typically less than 5% of total cancer cells based on cell surface marker e...

    Chenwei Li, C. J. Lee, Diane M. Simeone in Cancer Stem Cells (2009)

  12. No Access

    Reference Work Entry In depth

    Pancreatic Cancer Stem Cells

    Cheong J. Lee, David G. Heidt, Diane M. Simeone in Encyclopedia of Cancer (2009)