101 Result(s)
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Open AccessProposal and validation of a new approach in tele-rehabilitation with 3D human posture estimation: a randomized controlled trial in older individuals with sarcopenia
Through a randomized controlled trial on older adults with sarcopenia, this study compared the training effects of an AI-based remote training group using deep learning-based 3D human pose estimation technolog...
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Open AccessExperimental verification about treatment of Bu-Shen-Yi-**g-Fang in Alzheimer’s disease by the analysis of the feasible signaling pathway of network pharmacology
Bu-shen-yi-**g-fang (BSYJF) has been reported to reduce amyloid-β (Aβ)1–42 deposition in the brain of APP/PS1 mice and ameliorate cognitive function. However, its neuroprotective mechanism remains unclear.
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ZBTB16 inhibits DNA replication and induces cell cycle arrest by targeting WDHD1 transcription in lung adenocarcinoma
Lung adenocarcinoma is a malignant tumor with high morbidity and mortality. ZBTB16 plays a double role in various tumors; however, the potential mechanism of ZBTB16 in the pathophysiology of lung adenocarcinom...
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Open AccessAn immune-related adverse event of Behcet’s-like syndrome following pembrolizumab treatment
In recent years, the emergence of immunotherapy has renewed therapeutic modality. Different from traditional anti-tumor therapy, immune-related adverse events of skin, gastrointestinal tract, liver, lung, endo...
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Open AccessInforming immunotherapy with multi-omics driven machine learning
Progress in sequencing technologies and clinical experiments has revolutionized immunotherapy on solid and hematologic malignancies. However, the benefits of immunotherapy are limited to specific patient subse...
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Open AccessRituximab may affect T lymphocyte subsets balance in primary membranous nephropathy
The aim of this study was to investigate the effects and significance of rituximab (RTX) on the levels of T lymphocyte subsets in patients diagnosed with primary membranous nephropathy (PMN).
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Development of algorithms to estimate the EQ-5D-5L from the FACT-L in patients with lung cancer: a map** study
This study aimed to develop a map** algorithm to evaluate the EQ-5D-5L according to the FACT-L when the EQ-5D-5L is not available.
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Open AccessCorrection: Prediction of the SF-6D utility score from lung cancer FACT-L: a map** study in China
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Map** the EORTC QLQ-C30 and QLQ H&N35 to the EQ-5D-5L and SF-6D for papillary thyroid carcinoma
Empirical evidence for the EORTC QLQ C30 scale in thyroid cancer map** algorithms has not been found in China, which limits the cost-utility analysis of patients with papillary thyroid carcinoma (PTC) popula...
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Open AccessIntegrative study of pulmonary microbiome, transcriptome and clinical outcomes in Mycoplasma pneumoniae pneumonia
This study aimed to investigate the interactions among three core elements of respiratory infection—pathogen, lung microbiome, and host response—and their avocation with the severity and outcomes of Mycoplasma pn...
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Open AccessPrediction of the SF-6D utility score from Lung cancer FACT-L: a map** study in China
To develop a map** algorithm for generating the Short Form Six-Dimension (SF-6D) utility score based on the Functional Assessment of Cancer Therapy-Lung (FACT-L) of lung cancer patients.
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Article
S1P-S1PR3-RAS promotes the progression of S1PR3hi TAL1+ T-cell acute lymphoblastic leukemia that can be effectively inhibited by an S1PR3 antagonist
TAL1+ T-cell acute lymphoblastic leukemia (T-ALL) is a distinct subtype of leukemia with poor outcomes. Through the cooperation of co-activators, including RUNX1, GATA3, and MYB, the TAL1 oncoprotein extends the ...
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Open AccessThymic hyperplasia with lymphoepithelial sialadenitis (LESA)-like features: a case report and literature review
Thymic hyperplasia with lymphoepithelial sialadenitis-like features (LESA-like TH) is a rare form of thymic hyperplasia, characterized by a prominent expansion of the thymic medulla containing hyperplastic lym...
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Open AccessBody landmarks and genetic algorithm-based approach for non-contact detection of head forward posture among Chinese adolescents: revitalizing machine learning in medicine
Addressing the current complexities, costs, and adherence issues in the detection of forward head posture (FHP), our study conducted an exhaustive epidemiologic investigation, incorporating a comprehensive pos...
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Open AccessHeavy metals in drinking water and periodontitis: evidence from the national oral health survey from China
Periodontitis has become an increasingly important public health issue, coupled with a high economic burden for prevention and treatment. Exposure to essential trace heavy metals has been associated with vario...
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Open AccessCharacterizing the penumbras of white matter hyperintensities in patients with cerebral small vessel disease
The white matter hyperintensity penumbra (WMH-P) is the subtly changed normal-appearing white matter (NAWM) that surrounds white matter hyperintensities (WMHs). The goal of this study was to define WMH-P in ce...
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Open AccessExamining racial disparity in psychotic disorders related ambulatory care visits: an observational study using national ambulatory medical care survey 2010–2015
One of the most consistent research findings related to race and mental health diseases is the disproportionately high rate of psychotic disorder diagnoses among people of color, specifically people of African...
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Open AccessGastrointestinal symptoms of long COVID-19 related to the ectopic colonization of specific bacteria that move between the upper and lower alimentary tract and alterations in serum metabolites
Since the coronavirus disease 2019 (COVID-19) outbreak, many COVID-19 variants have emerged, causing several waves of pandemics and many infections. Long COVID-19, or long-term sequelae after recovery from COV...
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Log odds of positive lymph nodes show better predictive performance on the prognosis of early-onset colorectal cancer
As the incidence of colorectal cancer tends to be younger, early-onset colorectal cancer (EOCRC) has attracted more attention in recent years. We aimed to assess the optimal lymph node staging system among EOC...
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Open AccessSignificance of ypTNM stage in determining the prognosis and therapy after surgery for locally advanced rectal cancer
In the current NCCN guidelines, the prognosis and adjuvant chemotherapy of patients who underwent neoadjuvant chemoradiotherapy (nCRT) are based on pre-radiotherapy clinical TNM (cTNM) stage. However, the valu...
