8 Result(s)
-
Article
Open AccessA convenient, reliable, and fast acoustic pressure field measurement method for magnetic resonance-guided high-intensity focused ultrasound systems with phased array transducers
With the expanding applications of magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU), there is an urgent need for a convenient, reliable, and fast acoustic pressure field measurement method...
-
Article
A Molecular Imaging Paradigm to Rapidly Profile Response to Angiogenesis-directed Therapy in Small Animals
The development of novel angiogenesis-directed therapeutics is hampered by the lack of non-invasive imaging metrics capable of assessing treatment response. We report the development and validation of a novel ...
-
Protocol
Using In Vivo Biopanning for the Development of Radiation-Guided Drug Delivery Systems
This chapter illustrates our protocol for in vivo biopanning using T7 bacteriophage libraries for the purpose of selecting recombinant peptides for the tumor-specific delivery of radiosensitizers to radiation-...
-
Article
Enhanced radiation damage of tumor vasculature by mTOR inhibitors
It is known that radiation activates the phosphoinositol-3 kinase (PI3K)/Akt pathway and that inhibition of PI3K or Akt sensitizes tumor vasculature to radiotherapy. Mammalian target of rapamycin (mTOR) is a d...
-
Article
Erratum: XIAP and survivin as therapeutic targets for radiation sensitization in preclinical models of lung cancer
Correction to: Oncogene (2004) 23, 7047–7052. doi: 10.1038/sj.onc.1207929 Since publication of the above manuscript, the authors have identified an error in the ‘Materials and methods’ section of this paper. O...
-
Article
XIAP and survivin as therapeutic targets for radiation sensitization in preclinical models of lung cancer
Survivin and XIAP are members of inhibitors of apoptosis (IAPs) family. They are upregulated in various malignancies. Inactivation of these molecules has resulted in chemosensitization. The purpose of this stu...
-
Chapter
Role of Gene Therapy in Radiation Oncology
Optimization of the treatment of neoplasms with radiation therapy can be achieved by reduction of the radiation sensitivity of surrounding normal tissues, or by enhancement of the tumoricidal effects of radiat...
-
Chapter
Ionizing Radiation-Mediated Protein Kinase C Activation and Gene Expression
Ionizing radiation-induced neoplastic transformation is postulated to occur as a consequence of an initial common event followed by a rare second event. Genes encoding transcription factors are expressed immed...
