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Article
Open AccessEffects of aged garlic extract and FruArg on gene expression and signaling pathways in lipopolysaccharide-activated microglial cells
Aged garlic extract (AGE) is widely used as a dietary supplement on account of its protective effects against oxidative stress and inflammation. But less is known about specific molecular targets of AGE and it...
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Article
Botanical Polyphenols Mitigate Microglial Activation and Microglia-Induced Neurotoxicity: Role of Cytosolic Phospholipase A2
Microglia play a significant role in the generation and propagation of oxidative/nitrosative stress, and are the basis of neuroinflammatory responses in the central nervous system. Upon stimulation by endotoxi...
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Article
Withania somnifera and Its Withanolides Attenuate Oxidative and Inflammatory Responses and Up-Regulate Antioxidant Responses in BV-2 Microglial Cells
Withania somnifera (L.) Dunal, commonly known as Ashwagandha, has been used in Ayurvedic medicine for promoting health and quality of life. Recent clinical trials together with experiment...
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Article
Open AccessCorrection: Corrigendum: Discovery of a Novel Seminal Fluid Microbiome and Influence of Estrogen Receptor Alpha Genetic Status
Scientific Reports 6: Article number: 23027; published online: 14 March 2016; updated: 29 April 2016. In this Article, Figure 4 is a duplication of Figure 6. The correct Figure 4 appears below as Figure 1.
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Article
Open AccessDiscovery of a Novel Seminal Fluid Microbiome and Influence of Estrogen Receptor Alpha Genetic Status
Bacteria harbored in the male reproductive system may influence reproductive function and health of the male and result in developmental origins of adult health and disease (DOHaD) effects in his offspring. Su...
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Article
Open AccessMessenger RNA profile analysis deciphers new Esrrb responsive genes in prostate cancer cells
Orphan nuclear receptor estrogen related receptor β (Esrrb or ERRβ) is well known in stem cells and early embryonic development. However, little is known about its function in cancer.
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Article
Open AccessGenes targeted by the Hedgehog-signaling pathway can be regulated by Estrogen related receptor β
Nuclear receptor family member, Estrogen related receptor β, and the Hedgehog signal transduction pathway are both reported to relate to tumorigenesis and induced pluripotent stem cell reprogramming. We hypoth...
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Article
Open AccessNitroDIGE analysis reveals inhibition of protein S-nitrosylation by epigallocatechin gallates in lipopolysaccharide-stimulated microglial cells
Nitric oxide (NO) is a signaling molecule regulating numerous cellular functions in development and disease. In the brain, neuronal injury or neuroinflammation can lead to microglial activation, which induces ...
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Article
Open AccessMagnolia polyphenols attenuate oxidative and inflammatory responses in neurons and microglial cells
The bark of magnolia has been used in Oriental medicine to treat a variety of remedies, including some neurological disorders. Magnolol (Mag) and honokiol (Hon) are isomers of polyphenolic compounds from the b...
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Article
Genistein affects HER2 protein concentration, activation, and promoter regulation in BT-474 human breast cancer cells
The HER2 proto-oncogene, a member of the epidermal growth factor receptor family, is overexpressed in 20–30% of breast cancers. Genistein, the main soy isoflavone, interacts with estrogen receptors (ER) and it is...
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Article
Phytosterol Pygeum africanum regulates prostate cancer in vitro and in vivo
Prostate cancer is an important public health problem. It is an excellent candidate disease for chemo-prevention because prostate cancer is typically slow growing and is usually diagnosed in elderly males. Pygeum...
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Article
Steroid feedback on gonadotropin release and pituitary gonadotropin subunit mRNA in mice lacking a functional estrogen receptor α
Steroid hormones regulate levels of gonadotropin mRNA in the pituitary, and gonadotropic hormones in plasma. To determine whether estrogen receptor a (ERα) mediates steroid negative feedback, wild type (WT) an...
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Article
Hypermethylation of the Wilms' tumor suppressor gene CpG island in human breast carcinomas
CpG island hypermethylation is known to be associated with transcriptional silencing of tumor suppressor genes in neoplasia. We have previously detected aberrantly methylated sites in the first intron of the W...
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Article
A role for oestrogens in the male reproductive system
Oestrogen is considered to be the ‘female’ hormone, whereas testosterone is considered the ‘male’ hormone. However, both hormones are present in both sexes. Thus sexual distinctions are not qualitative differe...
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Article
Estrogen inhibits the vascular injury response in estrogen receptor α-deficient mice
The atheroprotective effects of estrogen in women are well recognized1, but the underlying mechanisms responsible are not well understood. Blood vessel cells express the classic estrogen receptor, ERα (ref. 2—6),...
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Chapter and Conference Paper
Androgen Regulation of Growth Factor and Early Growth Repsonse Gene Expression in Hamster DDT1-MF2 and Human Prostate LNCAP Cells
The Syrian hamster DDT-1 cell line was originally derived from an estrogen/androgen-induced ductus deferens tumor and has served as a model for analyzing androgen-induced growth (1). Likewise a human prostate ...
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Article
Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy
X-LINKED spinal and bulbar muscular atrophy (Kennedy's disease) is an adult-onset form of motorneuron disease which may be associated with signs of androgen insensitivity. We have now investigated whether the...
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Chapter
New Approaches to Studies on the Androgen Receptor
Recent advances in studies on the androgen receptor (AR) have led to the application of new technology to the question of receptor status in prostate disease. Critical to these advances has been the cloning of...
