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Article
Open AccessAI-assisted prediction of differential response to antidepressant classes using electronic health records
Antidepressant selection is largely a trial-and-error process. We used electronic health record (EHR) data and artificial intelligence (AI) to predict response to four antidepressants classes (SSRI, SNRI, bupr...
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Article
Open AccessCausal inference in medical records and complementary systems pharmacology for metformin drug repurposing towards dementia
Metformin, a diabetes drug with anti-aging cellular responses, has complex actions that may alter dementia onset. Mixed results are emerging from prior observational studies. To address this complexity, we dep...
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Article
APOE ε4 and late-life cognition: mediation by structural brain imaging markers
The apolipoprotein E allele 4 (APOE-ε4) is established as a major genetic risk factor for cognitive decline and late-onset Alzheimer’s disease. Accumulating evidence has linked ε4 carriership to abnormal structur...
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Article
Long-term intake of total energy and fat in relation to subjective cognitive decline
Diet is one of the modifiable risk factors for cognitive decline. However, human studies on total energy intake and cognitive function have remained limited and studies on fat intake and cognitive decline have...
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Article
Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
Risk for late-onset Alzheimer’s disease (LOAD), the most prevalent dementia, is partially driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association meta-analysis of clinicall...
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Article
Open AccessPolygenic pleiotropy and potential causal relationships between educational attainment, neurobiological profile, and positive psychotic symptoms
Event-related potential (ERP) components have been used to assess cognitive functions in patients with psychotic illness. Evidence suggests that among patients with psychosis there is a distinct heritable neur...
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Article
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
Sven van der Lee, Julie Williams, Gerard Schellenberg and colleagues identify rare coding variants in PLCG2, ABI3 and TREM2 associated with Alzheimer's disease. These genes are highly expressed in microglia and p...
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Article
Statins, cognition, and dementia—systematic review and methodological commentary
Initiation of statin use in late life does not seem to prevent cognitive decline and dementia over the subsequent few years
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Article
Early and late menarche and risk of depressive symptoms in young adulthood
We investigated whether girls experiencing early menarche have an increased risk of depression during young adulthood. This study used data collected in the Growing Up Today Study (N = 9,039), an ongoing prospect...
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Article
Classifying neurocognitive disorders: the DSM-5 approach
The fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) provides a framework for the diagnosis of neurocognitive disorders based...
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Article
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
Philippe Amouyel, Julie Williams, Gerard Schellenberg, Sudha Seshadri and colleagues report a meta-analysis of genome-wide association studies for late-onset Alzheimer's disease in 17,008 cases and 37,154 cont...
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Article
Open AccessProperties of permutation-based gene tests and controlling type 1 error using a summary statistic based gene test
The advent of genome-wide association studies has led to many novel disease-SNP associations, opening the door to focused study on their biological underpinnings. Because of the importance of analyzing these a...
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Article
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease
Gerard Schellenberg and colleagues report a genome-wide association study of late-onset Alzheimer's disease (LOAD), as part of the Alzheimer Disease Genetics Consortium. They identify common variants in MS4A4/MS4...
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Article
Failure of repetition suppression and memory encoding in aging and Alzheimer’s disease
The suppression of neural activity in the medial temporal lobe (MTL) has been suggested as a marker of successful recognition of familiarity in healthy subjects, but to be impaired in patients with Alzheimer’s...
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Article
Assessment of Alzheimer’s disease case–control associations using family-based methods
The genetics of Alzheimer’s disease (AD) is heterogeneous and remains only ill-defined. We have recently created a freely available and continuously updated online database (AlzGene; http://www...
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Article
Feasibility of Multi-site Clinical Structural Neuroimaging Studies of Aging Using Legacy Data
The application of advances in biomedical computing to medical imaging research is enabling scientists to conduct quantitative clinical imaging studies using data collected across multiple sites to test new hy...
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Article
Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database
The past decade has witnessed hundreds of reports declaring or refuting genetic association with putative Alzheimer disease susceptibility genes. This wealth of information has become increasingly difficult to...
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Article
Open AccessA QTL genome scan of the metabolic syndrome and its component traits
Because high blood pressure, altered lipid levels, obesity, and diabetes so frequently occur together, they are sometimes collectively referred to as the metabolic syndrome. While there have been many studies ...
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Genetic Testing in the Early Diagnosis of Alzheimer’s Disease
Given the clear role of genetic factors in the development of Alzheimer’s disease (AD), and the identification of several genes involved in the disease, genetic testing presents some interesting possibilities ...
