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Article
Open AccessAssociation between retinal microvascular abnormalities and late-life brain amyloid-β deposition: the ARIC-PET study
Retinal microvascular signs are accessible measures of early alterations in microvascular dysregulation and have been associated with dementia; it is unclear if they are associated with AD (Alzheimer’s disease...
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Article
Prediabetes, intervening diabetes and subsequent risk of dementia: the Atherosclerosis Risk in Communities (ARIC) study
The aim of this work was to evaluate whether the association of prediabetes with dementia is explained by the intervening onset of diabetes.
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Article
Open AccessMid-life serum Vitamin D concentrations were associated with incident dementia but not late-life neuropsychological performance in the Atherosclerosis Risk in Communities (ARIC) Study
Activated Vitamin D has anti-inflammatory properties and adequate 25-hydroxyvitamin D [25(OH)D] concentrations may be important for neurocognitive function and protection against neurologic injury. We examined...
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Article
Severe hypoglycaemia, mild cognitive impairment, dementia and brain volumes in older adults with type 2 diabetes: the Atherosclerosis Risk in Communities (ARIC) cohort study
We aimed to evaluate the link between severe hypoglycaemia and domain-specific cognitive decline, smaller brain volumes and dementia in adults with type 2 diabetes, which so far has been relatively poorly char...
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Article
Retinal microvascular calibre and risk of diabetes mellitus: a systematic review and participant-level meta-analysis
The calibre of the retinal vessels has been linked to diabetes mellitus but studies have not shown consistent results. We conducted a participant-level meta-analysis to evaluate the association between retinal...
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Article
Statins, cognition, and dementia—systematic review and methodological commentary
Initiation of statin use in late life does not seem to prevent cognitive decline and dementia over the subsequent few years
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Article
Open AccessThe association of the ankle-brachial index with incident coronary heart disease: the Atherosclerosis Risk In Communities (ARIC) study, 1987–2001
Peripheral arterial disease (PAD), defined by a low ankle-brachial index (ABI), is associated with an increased risk of cardiovascular events, but the risk of coronary heart disease (CHD) over the range of the...
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Article
Open AccessPulse pressure and age at menopause
The objective of this study was to study the association of early age at menopause with pulse pressure (PP), a marker of arterial stiffness, and PP change.
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Chapter and Conference Paper
Ultrasound Measurement of Atherosclerosis: Directions for Epidemiology
In the past, philosophers searched for the elixir which would prolong life indefinitely and alchemists tried to transmute base metals into gold and silver. Epidemiologists may be their 20th Century counterpart...
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Chapter and Conference Paper
Ultrasound Studies of Factors Associated with Early Atheromata: Design Considerations
Arterial imaging of atherosclerotic lesions by ultrasound can be used in epidemiological studies of factors associated with early atheromata. We believe that ultrasound is ready for this application. However, ...
