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  1. Article

    Open Access

    Frequency and impact of medication reviews for people aged 65 years or above in UK primary care: an observational study using electronic health records

    Medication reviews in primary care provide an opportunity to review and discuss the safety and appropriateness of a person’s medicines. However, there is limited evidence about access to and the impact of rout...

    Rebecca M. Joseph, Roger D. Knaggs, Carol A. C. Coupland, Amelia Taylor in BMC Geriatrics (2023)

  2. Article

    Open Access

    A randomised controlled trial investigating the clinical and cost-effectiveness of Alpha-Stim AID cranial electrotherapy stimulation (CES) in patients seeking treatment for moderate severity depression in primary care (Alpha-Stim-D Trial)

    Major depression is the second leading cause of years lost to disability worldwide and is a leading contributor to suicide. However, first-line antidepressants are only fully effective for 33%, and only 40% of...

    Shireen Patel, Clement Boutry, Priya Patel, Michael P. Craven, Boliang Guo in Trials (2022)

  3. Article

    Open Access

    The risk of all-cause and cause-specific mortality in people prescribed mirtazapine: an active comparator cohort study using electronic health records

    Studies have reported an increased risk of mortality among people prescribed mirtazapine compared to other antidepressants. The study aimed to compare all-cause and cause-specific mortality between adults pres...

    Rebecca M. Joseph, Ruth H. Jack, Richard Morriss, Roger David Knaggs in BMC Medicine (2022)

  4. Article

    Open Access

    Secondary care specialist visits made by children and young people prescribed antidepressants in primary care: a descriptive study using the QResearch database

    Antidepressants may be used to manage a number of conditions in children and young people including depression, anxiety, and obsessive-compulsive disorder. UK guidelines for the treatment of depression in chil...

    Ruth H. Jack, Rebecca M. Joseph, Carol Coupland, Debbie Butler in BMC Medicine (2020)