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Article
Open AccessUptake, effectiveness and safety of COVID-19 vaccines in individuals at clinical risk due to immunosuppressive drug therapy or transplantation procedures: a population-based cohort study in England
Immunocompromised individuals are at increased risk of severe COVID-19 outcomes, underscoring the importance of COVID-19 vaccination in this population. The lack of comprehensive real-world data on vaccine upt...
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Article
Open AccessPredicting the risk of pancreatic cancer in adults with new-onset diabetes: development and internal–external validation of a clinical risk prediction model
The National Institute for Health and Care Excellence (NICE) recommends that people aged 60+ years with newly diagnosed diabetes and weight loss undergo abdominal imaging to assess for pancreatic cancer. More ...
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Article
Open AccessEthnic disparities in COVID-19 outcomes: a multinational cohort study of 20 million individuals from England and Canada
Heterogeneous studies have demonstrated ethnic inequalities in the risk of SARS-CoV-2 infection and adverse COVID-19 outcomes. This study evaluates the association between ethnicity and COVID-19 outcomes in tw...
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Article
Open AccessDesign decisions and data completeness for experience sampling methods used in psychosis: systematic review
The experience sampling method (ESM) is an intensive longitudinal research method.
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Open AccessDevelopment and validation of personalised risk prediction models for early detection and diagnosis of primary liver cancer among the English primary care population using the QResearch® database: research protocol and statistical analysis plan
The incidence and mortality of liver cancer have been increasing in the UK in recent years. However, liver cancer is still under-studied. The Early Detection of Hepatocellular Liver Cancer (DeLIVER-QResearch) ...
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Article
Open AccessRecruitment to a large scale randomised controlled clinical trial in primary care: the Helicobacter Eradication Aspirin Trial (HEAT)
The Helicobacter Eradication Aspirin Trial (HEAT) is a multicentre, double blind, randomised controlled trial investigating whether Helicobacter (H.) pylori eradication reduces hospitalisation for peptic ulcer bl...
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Article
Open AccessThe risk of all-cause and cause-specific mortality in people prescribed mirtazapine: an active comparator cohort study using electronic health records
Studies have reported an increased risk of mortality among people prescribed mirtazapine compared to other antidepressants. The study aimed to compare all-cause and cause-specific mortality between adults pres...
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Article
Open AccessHormone replacement therapy in women with cancer and risk of cancer-specific mortality and cardiovascular disease: a protocol for a cohort study from Scotland and Wales
Hormone replacement therapy (HRT) is widely used and has proven benefits for women with menopausal symptoms. An increasing number of women with cancer experience menopausal symptoms but the safety of HRT use i...
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Article
Open AccessSecondary care specialist visits made by children and young people prescribed antidepressants in primary care: a descriptive study using the QResearch database
Antidepressants may be used to manage a number of conditions in children and young people including depression, anxiety, and obsessive-compulsive disorder. UK guidelines for the treatment of depression in chil...
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Article
Open AccessAntidepressant use and risk of adverse outcomes in people aged 20–64 years: cohort study using a primary care database
Antidepressants are one of the most commonly prescribed medications in young and middle-aged adults, but there is relatively little information on their safety across a range of adverse outcomes in this age gr...
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Article
Open AccessAntidepressant use and risk of epilepsy and seizures in people aged 20 to 64 years: cohort study using a primary care database
Epilepsy is a serious condition which can profoundly affect an individual’s life. While there is some evidence to suggest an association between antidepressant use and epilepsy and seizures it is conflicting a...
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Article
Open AccessMulticentre cluster randomised controlled trial evaluating implementation of a fire prevention Injury Prevention Briefing in children’s centres: study protocol
The UK has one of the highest fatality rates for deaths from fire-related injuries in children aged 0–14 years; these injuries have the steepest social gradient of all injuries in the UK. Children’s centres pr...
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Article
Open AccessSafety of antidepressants in adults aged under 65: protocol for a cohort study using a large primary care database
Antidepressants are among the most commonly prescribed drugs in primary care in England and their use is increasing. This is largely due to longer durations of treatment of depression. Observational studies ha...
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Article
Open AccessGetting back to work after injury: the UK Burden of Injury multicentre longitudinal study
Injuries to working age adults are common and place a considerable burden on health services accounting for more than 10% of GP sick notes and 14% of those claiming benefits because they are unable to work in ...
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Article
Open AccessThe impact of injuries study. multicentre study assessing physical, psychological, social and occupational functioning post injury - a protocol
Large numbers of people are killed or severely injured following injuries each year and these injuries place a large burden on health care resources. The majority of the severely injured are not fully recovere...
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Article
Open AccessExposure to statins and risk of common cancers: a series of nested case-control studies
Many studies and meta-analyses have investigated the effects of statins on cancer incidence but without showing consistent effects.
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Article
Open AccessPredicting the risk of Chronic Kidney Disease in Men and Women in England and Wales: prospective derivation and external validation of the QKidney®Scores
Chronic Kidney Disease is a major cause of morbidity and interventions now exist which can reduce risk. We sought to develop and validate two new risk algorithms (the QKidney® Scores) for estimating (a) the indiv...
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Article
Open AccessThe use of conspicuity aids by cyclists and risk of crashes involving other road users: a protocol for a population based case-control study
Regular cycling has been shown to improve health and has a role in tackling the threats posed by obesity and inactivity. Cycle collisions, particularly those involving motorised vehicles, can lead to significa...
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Article
Open AccessRandomised controlled trial of thermostatic mixer valves in reducing bath hot tap water temperature in families with young children in social housing: A protocol
Each year in the UK 2000 children attend emergency departments and 500 are admitted to hospital following a bath water scald. The long term effects can include disability, disfigurement or psychological harm a...
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Article
Open AccessThe UK Burden of Injury Study – a protocol. [National Research Register number: M0044160889]
Globally and nationally large numbers of people are injured each year, yet there is little information on the impact of these injuries on people's lives, on society and on health and social care services. Meas...
