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Study of repigmentation patterns and dermatoscopic features in vitiligo treated with various modalities
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Transcriptional variations at perilesional site in vitiligo patients: probably a fight for cell-survival
Exploration of gene expression variations is a potential source to unravel biological pathways involved in pathological changes in body and understand the mechanism underneath. Vitiligo patients were explored ...
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Article
Differential expression of extracellular matrix proteins in the lesional skin of vitiligo patients
Skin pigmentation is regulated by intricate interaction of the dermis and epidermis. The extracellular components present in the dermis play a very important role in the maintenance of skin homeostasis. Theref...
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Article
Chronic spontaneous urticaria and metabolic syndrome: a relationship conundrum
Chronic spontaneous urticaria (CSU) and metabolic syndrome (MetS) are associated with low-grade inflammation. Despite intensive research and various hypothesis, there is lack of specific pathomechanisms of urt...
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Article
Altered levels of lymphocyte enhancer-binding factor-1 modulates the pigmentation in acral and non-acral lesions of non-segmental vitiligo patients: a follow-up-based study in North India
Lymphocyte enhancer-binding factor-1 (LEF1) is responsible for melanocyte proliferation, migration and differentiation and its downregulation may result in depigmentation in vitiligo. Narrowband UVB (NB-UVB) p...
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A randomized, open-label study to compare two different dosing regimens of oral tranexamic acid in treatment of moderate to severe facial melasma
Oral tranexamic acid (TXA) demonstrates promising results in melasma management. However, no clear consensus on the dosing and duration of maintenance doses of TXA therapy in melasma exists. In this study, we ...
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Article
Catecholamines’ accumulation and their disturbed metabolism at perilesional site: a possible cause of vitiligo progression
Catecholamines (epinephrine, norepinephrine and dopamine) are considered toxic to the melanocytes and may play an important role in the development of depigmented patches on the skin. This study was done to ev...
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Article
Dendritic cells sub-sets are associated with inflammatory cytokine production in progressive vitiligo disease
In autoimmune onset of vitiligo, perilesional area shows inflammatory cells including T cytotoxic, helper cells and macrophages. Dendritic Cells (DCs) regulate immune activities by antigen presentation to T ce...
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Article
Oral mycophenolate mofetil as a stabilizing treatment for progressive non-segmental vitiligo: results from a prospective, randomized, investigator-blinded pilot study
Dexamethasone oral mini-pulse (OMP) is commonly used to halt progression of non-segmental vitiligo (NSV). There is an unmet need for non-phototherapy, non-corticosteroid therapeutic options for stabilizing act...
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Article
Significant reduction in the expression of interleukins-17A, 22 and 23A, forkhead box p3 and interferon gamma delineates lichen planus pigmentosus from lichen planus
Recent studies have noticed significant role of interleukin (IL)-17, 22, 23, Foxp3, interferon-gamma (IFN-γ) and Wnt5a in oral and cutaneous lichen planus (LP). This study was undertaken to assess whether simi...
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Chapter
Quality of Life
Vitiligo can induce considerable psychosocial stress and psychiatric comorbidity. Then, it is important to recognize and manage the psychological component not only to improve co** but also to obtain a bette...
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Chapter
Halo Nevus, Leucotrichia and Mucosal Vitiligo
Halo nevus is defined as a well-defined, symmetrical, round or oval, hypopigmented, or depigmented rim/halo around a central melanocytic nevus. The size of nevus and ring can vary from few millimeters to centi...
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Article
Effect of Dickkopf1 on the senescence of melanocytes: in vitro study
Fibroblasts secrete several growth factors which are important for the regulation of skin pigmentation. Dickkopf1 (DKK1) is also secreted by fibroblasts which inhibit the growth and function of melanocytes. Th...
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Article
sQUIZ your knowledge!: An indurated noduloplaque on the infraclavicular region of a female
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Recent Advances in Pathogenesis and Medical Management of Vitiligo
Vitiligo is a common pigmentary disorder characterised by the loss of functioning melanocytes from the basal layer of epidermis, leaving behind depigmented patches on the skin. It has a complex aetiopathology....
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Article
Senescence in the lesional fibroblasts of non-segmental vitiligo patients
Dermal fibroblasts secrete various growth factors which are important for skin pigmentation. Imbalance in the synchronization of epidermal and dermal cells in the skin can play vital role in the pathogenesis o...
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Article
Vitiligo
Vitiligo is an acquired depigmenting disorder that affects 0.5% to 2% of the world population. Three different forms are classified according to the distribution of lesions; namely non-segmental, segmental and...
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Article
Modulation of LXR-α and the effector genes by Ascorbic acid and Statins in psoriatic keratinocytes
Recent studies have revealed critical roles that nuclear receptors like LXR-α (Liver X Receptor- alpha) plays as a class of post-transcriptional gene regulator in skin development and diseases. Kee** in view...
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Chapter
Mucosal Vitiligo
Mucosal vitiligo (MV) can present as a part of involvement in vitiligo vulgaris, as an extension of perioral involvement of acrofacial viti-ligo, and as pu...
