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  1. No Access

    Article

    Pharmacokinetics of Commonly Used Antimicrobials in Critically Ill Pediatric Patients During Extracorporeal Membrane Oxygenation: A Systematic Review

    Adequate dosing of antimicrobials is critical to properly treat infections and limit development of resistance and adverse effects. Limited guidance exist for antimicrobial dosing adjustments in patients requi...

    Marc-Alexandre Duceppe, Salmaan Kanji, Anh Thu Do, Ni Ruo in Pediatric Drugs (2023)

  2. Article

    Pharmacological and non-pharmacological interventions to prevent delirium in critically ill patients: a systematic review and network meta-analysis

    To compare the effects of prevention interventions on delirium occurrence in critically ill adults.

    Lisa D. Burry, Wei Cheng, David R. Williamson, Neill K. Adhikari in Intensive Care Medicine (2021)

  3. No Access

    Article

    Pharmacokinetics of Commonly Used Antimicrobials in Critically Ill Adults During Extracorporeal Membrane Oxygenation: A Systematic Review

    Adequate dosing of antimicrobials is critical to properly treat infections and limit development of resistance and adverse effects. Limited guidance exists for antimicrobial dosing adjustments in patients requ...

    Marc-Alexandre Duceppe, Salmaan Kanji, Anh Thu Do, Ni Ruo in Drugs (2021)

  4. Article

    Open Access

    Agitation, confusion, and aggression in critically ill traumatic brain injury-a pilot cohort study (ACACIA-PILOT)

    Agitated behaviors are problematic in intensive care unit (ICU) patients recovering from traumatic brain injury (TBI) as they create substantial risks and challenges for healthcare providers. To date, there ha...

    David R. Williamson, Sofia Ihsenne Cherifa in Pilot and Feasibility Studies (2020)

  5. Article

    Strategies for the Prevention and Treatment of Iatrogenic Withdrawal from Opioids and Benzodiazepines in Critically Ill Neonates, Children and Adults: A Systematic Review of Clinical Studies

    Critically ill patients are at high risk of iatrogenic withdrawal syndrome (IWS), due to exposure to high doses or prolonged periods of opioids and benzodiazepines.

    Barbara Sneyers, Marc-Alexandre Duceppe, Anne Julie Frenette, Lisa D. Burry in Drugs (2020)

  6. No Access

    Article

    Metabolite monitoring to guide thiopurine therapy in systemic autoimmune diseases

    6-Thioguanine nucleotide (6-TGN) is the active metabolite of thiopurine drugs azathioprine and 6-mercaptopurine. 6-Methylmercaptopurine (6-MMP) is an inactive and potentially hepatotoxic metabolite. A subgroup...

    Aurélie Chapdelaine, Anne-Marie Mansour, Yves Troyanov in Clinical Rheumatology (2017)

  7. Article

    Open Access

    Pharmacological interventions for agitation in patients with traumatic brain injury: protocol for a systematic review and meta-analysis

    Traumatic brain injury (TBI) is a worldwide leading cause of mortality and disability. Among TBI complications, agitation is a frequent behavioural problem. Agitation causes potential harm to patients and care...

    David R. Williamson, Anne Julie Frenette, Lisa Burry in Systematic Reviews (2016)

  8. No Access

    Article

    Validation and comparison of CAM-ICU and ICDSC in mild and moderate traumatic brain injury patients

    Anne Julie Frenette, Emmanuel R. Bebawi, Louis C. Deslauriers in Intensive Care Medicine (2016)

  9. Article

    Open Access

    Albumin administration is associated with acute kidney injury in cardiac surgery: a propensity score analysis

    The risk of acute kidney injury (AKI) with the use of albumin-containing fluids compared to starches in the surgical intensive care setting remains uncertain. We evaluated the adjusted risk of AKI associated w...

    Anne Julie Frenette, Josée Bouchard, Pascaline Bernier, Annie Charbonneau in Critical Care (2014)

  10. Article

    Open Access

    Predictors of physical restraint use in Canadian intensive care units

    Physical restraint (PR) use in the intensive care unit (ICU) has been associated with higher rates of self-extubation and prolonged ICU length of stay. Our objectives were to describe patterns and predictors o...

    Elena Luk, Barbara Sneyers, Louise Rose, Marc M Perreault in Critical Care (2014)

  11. Article

    Open Access

    Size matters: modeling the effects of body shape on locomotive behavior in the nematode C. elegans

    David R Williamson, Netta Cohen in BMC Neuroscience (2012)

  12. No Access

    Article

    Drug-induced hepatic cholestasis in the critically ill

    Anne Julie Frenette, Marie-Eve Bédard Dufresne, Valérie Bonhomme in Intensive Care Medicine (2011)

  13. No Access

    Chapter

    Changes in Surface and Subsurface Temperatures after Clearing Forest in Western Australia

    Changes of ground surface temperature following clearing forest for agricultural development have been estimated using temperature-depth profiles measured in the Collie River Basin, Western Australia. Temperat...

    Makoto Taniguchi, David R. Williamson in Subsurface Hydrological Responses to Land … (1997)