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Article
Pharmacokinetics of Commonly Used Antimicrobials in Critically Ill Pediatric Patients During Extracorporeal Membrane Oxygenation: A Systematic Review
Adequate dosing of antimicrobials is critical to properly treat infections and limit development of resistance and adverse effects. Limited guidance exist for antimicrobial dosing adjustments in patients requi...
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Article
Pharmacological and non-pharmacological interventions to prevent delirium in critically ill patients: a systematic review and network meta-analysis
To compare the effects of prevention interventions on delirium occurrence in critically ill adults.
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Article
Pharmacokinetics of Commonly Used Antimicrobials in Critically Ill Adults During Extracorporeal Membrane Oxygenation: A Systematic Review
Adequate dosing of antimicrobials is critical to properly treat infections and limit development of resistance and adverse effects. Limited guidance exists for antimicrobial dosing adjustments in patients requ...
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Article
Open AccessAgitation, confusion, and aggression in critically ill traumatic brain injury-a pilot cohort study (ACACIA-PILOT)
Agitated behaviors are problematic in intensive care unit (ICU) patients recovering from traumatic brain injury (TBI) as they create substantial risks and challenges for healthcare providers. To date, there ha...
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Article
Strategies for the Prevention and Treatment of Iatrogenic Withdrawal from Opioids and Benzodiazepines in Critically Ill Neonates, Children and Adults: A Systematic Review of Clinical Studies
Critically ill patients are at high risk of iatrogenic withdrawal syndrome (IWS), due to exposure to high doses or prolonged periods of opioids and benzodiazepines.
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Article
Metabolite monitoring to guide thiopurine therapy in systemic autoimmune diseases
6-Thioguanine nucleotide (6-TGN) is the active metabolite of thiopurine drugs azathioprine and 6-mercaptopurine. 6-Methylmercaptopurine (6-MMP) is an inactive and potentially hepatotoxic metabolite. A subgroup...
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Article
Open AccessPharmacological interventions for agitation in patients with traumatic brain injury: protocol for a systematic review and meta-analysis
Traumatic brain injury (TBI) is a worldwide leading cause of mortality and disability. Among TBI complications, agitation is a frequent behavioural problem. Agitation causes potential harm to patients and care...
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Article
Validation and comparison of CAM-ICU and ICDSC in mild and moderate traumatic brain injury patients
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Article
Open AccessAlbumin administration is associated with acute kidney injury in cardiac surgery: a propensity score analysis
The risk of acute kidney injury (AKI) with the use of albumin-containing fluids compared to starches in the surgical intensive care setting remains uncertain. We evaluated the adjusted risk of AKI associated w...
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Article
Open AccessPredictors of physical restraint use in Canadian intensive care units
Physical restraint (PR) use in the intensive care unit (ICU) has been associated with higher rates of self-extubation and prolonged ICU length of stay. Our objectives were to describe patterns and predictors o...
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Article
Open AccessSize matters: modeling the effects of body shape on locomotive behavior in the nematode C. elegans
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Article
Drug-induced hepatic cholestasis in the critically ill
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Chapter
Changes in Surface and Subsurface Temperatures after Clearing Forest in Western Australia
Changes of ground surface temperature following clearing forest for agricultural development have been estimated using temperature-depth profiles measured in the Collie River Basin, Western Australia. Temperat...