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  1. Article

    Open Access

    Dual [68Ga]DOTATATE and [18F]FDG PET/CT in patients with metastatic gastroenteropancreatic neuroendocrine neoplasms: a multicentre validation of the NETPET score

    Gastroenteropancreatic neuroendocrine neoplasms (GEPNENs) are heterogeneous in clinical course, biology, and outcomes. The NETPET score predicts survival by scoring uptake on dual [68Ga]DOTATATE and [18F]FDG PET/...

    David L. Chan, Aimee R. Hayes, Ioannis Karfis, Alice Conner… in British Journal of Cancer (2023)

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  2. No Access

    Article

    Overall survival with circulating tumor DNA-guided therapy in advanced non-small-cell lung cancer

    Circulating tumor DNA (ctDNA) sequencing guides therapy decisions but has been studied mostly in small cohorts without sufficient follow-up to determine its influence on overall survival. We prospectively foll...

    Justin Jee, Emily S. Lebow, Randy Yeh, Jeeban P. Das, Azadeh Namakydoust… in Nature Medicine (2022)

  3. No Access

    Article

    Computed tomography (CT)-defined sarcopenia and myosteatosis are prevalent in patients with neuroendocrine neoplasms (NENs) treated with peptide receptor radionuclide therapy (PRRT)

    Neuroendocrine neoplasms (NEN) may predispose patients to malnutrition. CT-defined sarcopenia and myosteatosis are common in other tumour types and recognized adverse prognostic factors. However, the prevalenc...

    David L. Chan, Stephen J. Clarke, Alexander Engel… in European Journal of Clinical Nutrition (2022)

  4. Article

    Open Access

    Life-threatening diarrhea in neuroendocrine tumors: two case reports

    Neuroendocrine tumors are rare, heterogeneous neoplasms that produce a wide variety of clinical symptoms. Diarrhea in neuroendocrine tumors is incredibly common and is usually benign in nature. We report two e...

    Emma Gordon, David L. Chan, Jennifer Arena… in Journal of Medical Case Reports (2021)

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  5. No Access

    Article

    Are We Choosing Surveillance Imaging in Gastric and Pancreatic Cancers Wisely? A Population-Based Study

    Although gastric and pancreatic cancers are aggressive, there is no evidence that early detection of recurrence improves overall survival. We aimed to measure the frequency of surveillance imaging in patients ...

    David L Chan, Matthew Cheung, Craig C. Earle… in Journal of Gastrointestinal Cancer (2020)

  6. No Access

    Chapter

    Therapy for Metastatic Disease: Ileum

    The ileum is one of the most common primary sites for neuroendocrine tumours and the most common site of GI NETs. Approximately half will present as locoregionally advanced or metastatic disease. Patients with...

    David L. Chan, Eva Segelov, Simron Singh in Neuroendocrine Tumors in Real Life (2018)

  7. No Access

    Article

    Escalated-dose somatostatin analogues for antiproliferative effect in GEPNETS: a systematic review

    Somatostatin analogues are the cornerstone of systemic therapy for metastatic well-differentiated gastroenteropancreatic neuroendocrine tumours for both hormonal control and antiproliferative effect. Dose esca...

    David L. Chan, Diego Ferone, Manuela Albertelli, Nick Pavlakis, Eva Segelov… in Endocrine (2017)

  8. Chapter and Conference Paper

    Discovering User Interface Requirements of Search Results for Mobile Clients by Contextual Inquiry

    This paper reports our in situ study using contextual inquiry (CI). It solicits user requirements of hierarchically organized search results for mobile access. In our experiment, search activities of our subjects...

    David L. Chan, Robert W. P. Luk… in Human Interface and the Management of Info… (2009)

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