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    Article

    Molecular classification of papillary thyroid carcinoma: distinct BRAF, RAS, and RET/PTC mutation-specific gene expression profiles discovered by DNA microarray analysis

    Thyroid cancer poses a significant clinical challenge, and our understanding of its pathogenesis is incomplete. To gain insight into the pathogenesis of papillary thyroid carcinoma, transcriptional profiles of...

    Thomas J Giordano, Rork Kuick, Dafydd G Thomas, David E Misek, Michelle Vinco… in Oncogene (2005)

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    Article

    Increased C-CRK proto-oncogene expression is associated with an aggressive phenotype in lung adenocarcinomas

    The C-CRK gene, cellular homolog of the avian v-crk oncogene, encodes two alternatively spliced adaptor signaling proteins, CRKI (28 kDa) and CRKII (40 kDa). Both CRKI and CRKII have been shown to activate kinase...

    Charles T Miller, Guoan Chen, Tarek G Gharib, Hong Wang, Dafydd G Thomas… in Oncogene (2003)

  3. Article

    Profiling of pathway-specific changes in gene expression following growth of human cancer cell lines transplanted into mice

    Tumor cells cultured in vitro are widely used to investigate the molecular biology of cancers and to evaluate responses to drugs and other agents. The full extent to which gene expression in cancer cells is modul...

    Chad Creighton, Rork Kuick, David E Misek, David S Rickman… in Genome Biology (2003)

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