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  1. No Access

    Article

    Clonal evolution during metastatic spread in high-risk neuroblastoma

    Patients with high-risk neuroblastoma generally present with widely metastatic disease and often relapse despite intensive therapy. As most studies to date focused on diagnosis-relapse pairs, our understanding...

    Gunes Gundem, Max F. Levine, Stephen S. Roberts, Irene Y. Cheung… in Nature Genetics (2023)

  2. No Access

    Article

    The context-specific role of germline pathogenicity in tumorigenesis

    Human cancers arise from environmental, heritable and somatic factors, but how these mechanisms interact in tumorigenesis is poorly understood. Studying 17,152 prospectively sequenced patients with cancer, we ...

    Preethi Srinivasan, Chaitanya Bandlamudi, Philip Jonsson, Yelena Kemel… in Nature Genetics (2021)

  3. No Access

    Article

    Clinical cancer genomic profiling

    Technological innovation and rapid reduction in sequencing costs have enabled the genomic profiling of hundreds of cancer-associated genes as a component of routine cancer care. Tumour genomic profiling can re...

    Debyani Chakravarty, David B. Solit in Nature Reviews Genetics (2021)

  4. No Access

    Article

    The association between tumor mutational burden and prognosis is dependent on treatment context

    In multiple cancer types, high tumor mutational burden (TMB) is associated with longer survival after treatment with immune checkpoint inhibitors (ICIs). The association of TMB with survival outside of the imm...

    Cristina Valero, Mark Lee, Douglas Hoen, **gming Wang, Zaineb Nadeem… in Nature Genetics (2021)

  5. No Access

    Article

    Cancer therapy shapes the fitness landscape of clonal hematopoiesis

    Acquired mutations are pervasive across normal tissues. However, understanding of the processes that drive transformation of certain clones to cancer is limited. Here we study this phenomenon in the context of...

    Kelly L. Bolton, Ryan N. Ptashkin, Teng Gao, Lior Braunstein… in Nature Genetics (2020)

  6. No Access

    Article

    Tumor mutational load predicts survival after immunotherapy across multiple cancer types

    Immune checkpoint inhibitor (ICI) treatments benefit some patients with metastatic cancers, but predictive biomarkers are needed. Findings in selected cancer types suggest that tumor mutational burden (TMB) ma...

    Robert M. Samstein, Chung-Han Lee, Alexander N. Shoushtari… in Nature Genetics (2019)

  7. No Access

    Article

    Genome doubling shapes the evolution and prognosis of advanced cancers

    Ploidy abnormalities are a hallmark of cancer, but their impact on the evolution and outcomes of cancers is unknown. Here, we identified whole-genome doubling (WGD) in the tumors of nearly 30% of 9,692 prospec...

    Craig M. Bielski, Ahmet Zehir, Alexander V. Penson, Mark T. A. Donoghue… in Nature Genetics (2018)

  8. No Access

    Article

    Frequent somatic CDH1 loss-of-function mutations in plasmacytoid variant bladder cancer

    David Solit and colleagues report that inactivating CDH1 mutations are found in 84% of plasmacytoid bladder cancer samples tested and are not found in other bladder cancer subtypes. CRISPR/Cas9-mediated knockout ...

    Hikmat A Al-Ahmadie, Gopa Iyer, Byron H Lee, Sasinya N Scott… in Nature Genetics (2016)

  9. No Access

    Article

    Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion

    Matthew Meyerson and colleagues report the whole-genome sequencing of primary colorectal tumors and matched adjacent non-tumor tissue from nine individuals with colorectal cancer. They identify a recurrent VTI1A-...

    Adam J Bass, Michael S Lawrence, Lear E Brace, Alex H Ramos, Yotam Drier… in Nature Genetics (2011)

  10. No Access

    Article

    Somatic mutations of the Parkinson's disease–associated gene PARK2 in glioblastoma and other human malignancies

    Germline mutations in PARK2 are a well-known cause of the neurodegenerative disorder Parkinson's disease. Here, Timothy Chan and colleagues report somatic mutations and intragenic deletions of PARK2 in glioblasto...

    Selvaraju Veeriah, Barry S Taylor, Shasha Meng, Fang Fang… in Nature Genetics (2010)