16 Result(s)
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Darren C. Henstridge
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Open AccessClass IIa HDACs inhibit cell death pathways and protect muscle integrity in response to lipotoxicity
Lipotoxicity, the accumulation of lipids in non-adipose tissues, alters the metabolic transcriptome and mitochondrial metabolism in skeletal muscle. The mechanisms involved remain poorly understood. Here we sh...
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Author Correction: Sex-specific adipose tissue imprinting of regulatory T cells
A Correction to this paper has been published: https://doi.org/10.1038/s41586-020-2251-7
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Open AccessDeletion of Trim28 in committed adipocytes promotes obesity but preserves glucose tolerance
The effective storage of lipids in white adipose tissue (WAT) critically impacts whole body energy homeostasis. Many genes have been implicated in WAT lipid metabolism, including tripartite motif containing 28 (T...
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MCL-1 is essential for survival but dispensable for metabolic fitness of FOXP3+ regulatory T cells
FOXP3+ regulatory T (Treg) cells are essential for maintaining immunological tolerance. Given their importance in immune-related diseases, cancer and obesity, there is increasing interest in targeting the Treg ce...
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Fructose stimulated de novo lipogenesis is promoted by inflammation
Benign hepatosteatosis, affected by lipid uptake, de novo lipogenesis and fatty acid (FA) oxidation, progresses to non-alcoholic steatohepatitis (NASH) on stress and inflammation. A key macronutrient proposed ...
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Serine administration as a novel prophylactic approach to reduce the severity of acute pancreatitis during diabetes in mice
Compared with the general population, individuals with diabetes have a higher risk of develo** severe acute pancreatitis, a highly debilitating and potentially lethal inflammation of the exocrine pancreas. I...
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Sex-specific adipose tissue imprinting of regulatory T cells
Adipose tissue is an energy store and a dynamic endocrine organ1,2. In particular, visceral adipose tissue (VAT) is critical for the regulation of systemic metabolism3,4. Impaired VAT function—for example, in obe...
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Treatment of type 2 diabetes with the designer cytokine IC7Fc
The gp130 receptor cytokines IL-6 and CNTF improve metabolic homeostasis but have limited therapeutic use for the treatment of type 2 diabetes. Accordingly, we engineered the gp130 ligand IC7Fc, in which one g...
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Open AccessCorrection: Corrigendum: 14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function
Nature Communications 7: Article number: 12862 (2016); Published: 27 September 2016; Updated: 30 August 2017 In Supplementary Fig. 7 of this Article, graphs presenting 6-PFK kinetics in panel d were inadverten...
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Open AccessMuscle-specific overexpression of AdipoR1 or AdipoR2 gives rise to common and discrete local effects whilst AdipoR2 promotes additional systemic effects
Hypoadiponectinemia and adiponectin resistance are implicated in the aetiology of obesity-related cardiometabolic disorders, hence represent a potential therapeutic axis. Here we characterised the effects of in v...
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Open Access14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function
The 14-3-3 family of adaptor proteins regulate diverse cellular functions including cell proliferation, metabolism, adhesion and apoptosis. Platelets express numerous 14-3-3 isoforms, including 14-3-3ζ, which ...
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Genetic manipulation of cardiac Hsp72 levels does not alter substrate metabolism but reveals insights into high-fat feeding-induced cardiac insulin resistance
Heat shock protein 72 (Hsp72) protects cells against a variety of stressors, and multiple studies have suggested that Hsp72 plays a cardioprotective role. As skeletal muscle Hsp72 overexpression can protect ag...
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The small-molecule BGP-15 protects against heart failure and atrial fibrillation in mice
Heart failure (HF) and atrial fibrillation (AF) share common risk factors, frequently coexist and are associated with high mortality. Treatment of HF with AF represents a major unmet need. Here we show that a ...
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Correction: Corrigendum: The transcription factor IRF4 is essential for TCR affinity–mediated metabolic programming and clonal expansion of T cells
Nat. Immunol. 14, 1155–1165 (2013); published online 22 September 2013; corrected after print 8 January 2014 In the version of this article initially published, the scale of the top row (Naive) for S1pr1 in Fi...
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The transcription factor IRF4 is essential for TCR affinity–mediated metabolic programming and clonal expansion of T cells
Clonal expansion of cytotoxic T lymphocytes entails profound energetic demands. Kallies and colleagues show that the transcription factor IRF4 is critical for the metabolic reprogramming, survival and effector...
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Hsp72 preserves muscle function and slows progression of severe muscular dystrophy
Increasing the expression of intramuscular heat shock protein 72 preserves muscle strength and ameliorates the dystrophic pathology in two mouse models of muscular dystrophy, suggesting a promising way forward...
