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  1. Article

    Open Access

    Sickle Cell Disease Treatment with Arginine Therapy (STArT): study protocol for a phase 3 randomized controlled trial

    Despite substantial illness burden and healthcare utilization conferred by pain from vaso-occlusive episodes (VOE) in children with sickle cell disease (SCD), disease-modifying therapies to effectively treat S...

    Chris A. Rees, David C. Brousseau, Daniel M. Cohen, Anthony Villella… in Trials (2023)

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  2. No Access

    Article

    Novel urine biomarkers to distinguish UTI from culture-negative pyuria

    Emergency departments (EDs) often rely on urinalysis (UA) to rapidly identify urinary tract infections (UTIs) in children. However, the suboptimal test characteristics of UA can lead to false-positive results....

    Elaise B Hill, Joshua R Watson, Daniel M Cohen, David Kline… in Pediatric Nephrology (2022)

  3. No Access

    Article

    Corticosteroids to prevent kidney scarring in children with a febrile urinary tract infection: a randomized trial

    To evaluate the efficacy of adjuvant systemic corticosteroids in reducing kidney scarring. A previous study suggested that use of adjuvant systemic corticosteroids reduces kidney scarring in children radiologi...

    Nader Shaikh, Timothy R. Shope, Alejandro Hoberman… in Pediatric Nephrology (2020)

  4. No Access

    Article

    IgG-cleaving endopeptidase enables in vivo gene therapy in the presence of anti-AAV neutralizing antibodies

    Neutralizing antibodies to adeno-associated virus (AAV) vectors are highly prevalent in humans1,2, and block liver transduction3–5 and vector readministration6; thus, they represent a major limitation to in vivo ...

    Christian Leborgne, Elena Barbon, Jeffrey M. Alexander, Hayley Hanby… in Nature Medicine (2020)

  5. Article

    Evaluation of novel urinary tract infection biomarkers in children

    Pediatricians frequently use urinalysis to diagnose urinary tract infection (UTI) while awaiting urine culture results, but sensitivity and specificity of urinalysis are limited. This study evaluated the diagn...

    Joshua R. Watson, David S. Hains, Daniel M. Cohen, John David Spencer… in Pediatric Research (2016)

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  6. No Access

    Article

    Spontaneous diaphragm rupture associated with vaginal delivery

    Spontaneous rupture of the diaphragm associated with vaginal delivery is a rare occurrence, but has high rates of morbidity and mortality. Herein, we present a first uncomplicated case of spontaneous rupture o...

    Masatsugu Hamaji, Bryan M. Burt… in General Thoracic and Cardiovascular Surgery (2013)

  7. No Access

    Article

    Degradation-mediated cellular traction directs stem cell fate in covalently crosslinked three-dimensional hydrogels

    Although cell–matrix adhesive interactions are known to regulate stem cell differentiation, the underlying mechanisms, in particular for direct three-dimensional encapsulation within hydrogels, are poorly unde...

    Sudhir Khetan, Murat Guvendiren, Wesley R. Legant, Daniel M. Cohen… in Nature Materials (2013)

  8. No Access

    Protocol

    Measuring Cell–Cell Tugging Forces Using Bowtie-Patterned mPADs (Microarray Post Detectors)

    Cells generate traction forces upon adhesion to the extracellular matrix as well as to neighboring cells. These forces are important for the growth and maintenance of adhesion structures such as focal adhesion...

    Daniel M. Cohen, Mike T. Yang, Christopher S. Chen in Cell-Cell Interactions (2013)

  9. No Access

    Article

    Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues

    Tissues with perfusable vascular networks can be fabricated through layer-by-layer assembly, bioprinting or sacrificial moulding, but current approaches are slow, have limited resolution, or place significant ...

    Jordan S. Miller, Kelly R. Stevens, Michael T. Yang, Brendon M. Baker… in Nature Materials (2012)

  10. No Access

    Article

    Measurement of mechanical tractions exerted by cells in three-dimensional matrices

    Tracking the displacement of fluorescent beads surrounding a cell embedded in a hydrogel matrix allows quantitative measurement of the three-dimensional traction forces exerted by the cell.

    Wesley R Legant, Jordan S Miller, Brandon L Blakely, Daniel M Cohen… in Nature Methods (2010)

  11. No Access

    Article

    Structural basis for vinculin activation at sites of cell adhesion

    Vinculin is a highly conserved intracellular protein with a crucial role in the maintenance and regulation of cell adhesion and migration1,2,3. In the cytosol, vinculin adopts a default autoinhibited conformation

    Constantina Bakolitsa, Daniel M. Cohen, Laurie A. Bankston, Andrey A. Bobkov… in Nature (2004)

  12. No Access

    Article

    Massive thymolipoma involving both chest cavities

    Thymolipoma is a rare tumor composed of both adipose and mature thymic elements which may grow to very large sizes before becoming symptomatic. Since thymolipomas are benign tumors and do not invade adjacent s...

    Hilton Hudson, Daniel M. Cohen, Randolph Cribbs… in Pediatric Surgery International (1995)

  13. No Access

    Article

    Sexual Maturity and Migratory Behaviour of the Tropical Eel, Ahlia egmontis

    Ahlia egmontis (Jordan) (Fig. 1) is a ubiquitous shallow water worm eel of the tropical western Atlantic. It is abundant in canals and natural channels near the southern tip of Florida1 and in tidal creeks and pr...

    DANIEL M. COHEN, DAVID DEAN in Nature (1970)