33 Result(s)
within
Dan Luo
Life Sciences
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Article
Open Access15N-DNA stable isotope probing reveals niche differentiation of ammonia oxidizers in paddy soils
Chemoautotrophic canonical ammonia oxidizers (ammonia-oxidizing archaea (AOA) and ammonia-oxidizing bacteria (AOB)) and complete ammonia oxidizers (comammox Nitrospira) are accountable for ammonia oxidation, whic...
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Liquiritin alleviates LPS-stimulated podocyte apoptosis and inflammation by activating Nrf2 signaling
The kidney is one of the most vulnerable organs during the pathogenesis of sepsis. Regulating podocyte injury may be helpful for the treatment of acute kidney injury (AKI) after sepsis. Liquiritin is a flavono...
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Open AccesscircRNA-SFMBT2 orchestrates ERα activation to drive tamoxifen resistance in breast cancer cells
Dysregulated ERα signaling is responsible for endocrine resistance and eventual relapse in patients with estrogen receptor-positive (ER+) breast cancer. Thus, identifying novel ERα regulators is necessary to full...
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Open AccessCancer-associated fibroblasts facilitate breast cancer progression through exosomal circTBPL1-mediated intercellular communication
Breast cancer is the major common malignancy worldwide among women. Previous studies reported that cancer-associated fibroblasts (CAFs) showed pivotal roles in regulating tumor progression via exosome-mediated...
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Open AccessHSPB1 facilitates chemoresistance through inhibiting ferroptotic cancer cell death and regulating NF-κB signaling pathway in breast cancer
Chemoresistance is one of the major causes of therapeutic failure and poor prognosis for breast cancer patients, especially for triple-negative breast cancer patients. However, the underlying mechanism remains...
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Comparative Study of Two Common In Vitro Models for the Pancreatic Islet with MIN6
Islet transplantation is currently considered the most promising method for treating insulin-dependent diabetes. The two most-studied artificial islets are alginate-encapsulated β cells or β cell spheroids. As...
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Niacin mitigates rumen epithelial damage in vivo by inhibiting rumen epithelial cell apoptosis on a high concentrate diet
To investigate the effects of niacin on rumen fermentation, rumen epithelial antioxidant activity, and rumen epithelial cell apoptosis on high concentrate (HC) diets, nine male Hu sheep were randomly fed one o...
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Open AccessTRIM22 suppresses Zika virus replication by targeting NS1 and NS3 for proteasomal degradation
Recognition of viral invasion by innate antiviral immune system triggers activation of the type I interferon (IFN-I) and proinflammatory signaling pathways. Subsequently, IFN-I induction regulates expression o...
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Protective Effects of Lactobacillus rhamnosus Peptides Against DSS-Induced Inflammatory and Oxidative Damages in Human Colonic Epithelial Cells Through NF-κB/Nrf2/HO-1 Signaling Pathway
The bio-active function of intestinal microbiota and its metabolites, particularly short-chain fatty acids (SCFAs) against ulcerative colitis have been widely explored. However, the anti-oxidative and anti-inf...
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Association between TAP gene polymorphisms and tuberculosis susceptibility in a Han Chinese population in Guangdong
Tuberculosis (TB) is an important public health problem. Studies indicated that TAP plays a key role in the presentation and transport of antigenic peptides during anti-M.tb infection. Given the important biologi...
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Open AccessCombined effects of hyperthermia and chemotherapy on the regulate autophagy of oral squamous cell carcinoma cells under a hypoxic microenvironment
Autophagy has a complex dual role in tumor survival or cell death owning to that is an evolutionarily conserved catabolic mechanism and provides the cells with a sustainable source of biomolecules and energy f...
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Open AccessResearch on the drought tolerance mechanism of Pennisetum glaucum (L.) in the root during the seedling stage
Drought is one of the major environmental stresses resulting in a huge reduction in crop growth and biomass production. Pearl millet (Pennisetum glaucum L.) has excellent drought tolerance, and it could be used a...
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Cyclophilin A: a key player for etiological agent infection
Cyclophilin A (CypA), a key member of the immunophilin family, is the most abundantly expressed isozyme of the 18 known human cyclophilins. Besides acting as an intracellular receptor for cyclosporine A, CypA ...
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Open AccessModeling drug mechanism of action with large scale gene-expression profiles using GPAR, an artificial intelligence platform
Querying drug-induced gene expression profiles with machine learning method is an effective way for revealing drug mechanism of actions (MOAs), which is strongly supported by the growth of large scale and high...
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Open AccessNerylneryl diphosphate is the precursor of serrulatane, viscidane and cembrane-type diterpenoids in Eremophila species
Eremophila R.Br. (Scrophulariaceae) is a diverse genus of plants with species distributed across semi-arid and arid Australia. It is an ecologically important genus that also holds cultural significance for many ...
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Screening and Identification of the Binding Peptides of Mycoplasma genitalium Protein of Adhesion
Mycoplasma genitalium protein of adhesion (MgPa) is a vital membrane protein, which plays an important role in mediating the adhesion and infection of M. genitalium to host cells. This study aims to screen and id...
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Current understanding of genetic and molecular basis of cold tolerance in rice
Rice (Oryza sativa L.) is one of the most important crops worldwide, but its growth and production can be severely affected by climate change. As a tropical species, rice is in general vulnerable to the adverse e...
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Ribokinase screened from T7 phage displayed Mycobacterium tuberculosis genomic DNA library had good potential for the serodiagnosis of tuberculosis
Tuberculosis caused by Mycobacterium tuberculosis (M. tuberculosis) is the leading cause of death among infectious diseases in the worldwide. Lack of more sensitive and effective diagnostic reagents has increased...
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Open AccessLife history traits in a capital breeding pine caterpillar: effect of host species and needle age
For capital breeding Lepidoptera, larval food quality is a key determinant of their fitness. A series of studies have suggested that the larval host species or varieties dramatically impact their development a...
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Pollen magnetofection for genetic modification with magnetic nanoparticles as gene carriers
Genetic modification plays a vital role in breeding new crops with excellent traits. Almost all the current genetic modification methods require regeneration from tissue culture, involving complicated, long an...
