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  1. Article

    Accelerating drug repurposing for COVID-19 treatment by modeling mechanisms of action using cell image features and machine learning

    The novel coronavirus disease, COVID-19, has rapidly spread worldwide. Develo** methods to identify the therapeutic activity of drugs based on phenotypic data can improve the efficiency of drug development. ...

    Lu Han, Guangcun Shan, Bingfeng Chu, Hongyu Wang, Zhongjian Wang in Cognitive Neurodynamics (2023)

  2. Article

    Open Access

    Modeling drug mechanism of action with large scale gene-expression profiles using GPAR, an artificial intelligence platform

    Querying drug-induced gene expression profiles with machine learning method is an effective way for revealing drug mechanism of actions (MOAs), which is strongly supported by the growth of large scale and high...

    Shengqiao Gao, Lu Han, Dan Luo, Gang Liu, Zhiyong **ao, Guangcun Shan in BMC Bioinformatics (2021)