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Article
Open AccessiGenSig-Rx: an integral genomic signature based white-box tool for modeling cancer therapeutic responses using multi-omics data
Multi-omics sequencing is poised to revolutionize clinical care in the coming decade. However, there is a lack of effective and interpretable genome-wide modeling methods for the rational selection of patients...
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Article
Open AccessThe bending of a supra-subduction zone produced crustal thickening and arc migration of the Mongolian Orocline
Orogenic curvatures have been widely recognized along global convergent plate boundaries. Understanding the impact of such curvatures on the tectonic evolution of orogens and their three-dimensional architectu...
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Article
Large-Deformation Electrothermal Actuation Inchworm-Like Crawling Robot Based on Bistable Structures for Load Carrying
Crawling robots have great potential in some harsh environments, but there are still some limitations, such as tiny structures that can only produce small deformation and poor load-carrying capacity. A lightwe...
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Article
Open AccessAssociation between the atherogenic index of plasma and left ventricular hypertrophy in patients with obstructive sleep apnea: a retrospective cross-sectional study
The atherogenic index of plasma (AIP) is a simple and reliable marker of insulin resistance and is closely associated with various cardiovascular diseases (CVDs). However, the relationships between AIP and lef...
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Article
Open AccessClathrin mediates membrane fission and budding by constricting membrane pores
Membrane budding, which underlies fundamental processes like endocytosis, intracellular trafficking, and viral infection, is thought to involve membrane coat-forming proteins, including the most observed clath...
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Article
DNAJ protein gene expansion mechanism in Panicoideae and PgDNAJ functional identification in pearl millet
Analyze the evolutionary pattern of DNAJ protein genes in the Panicoideae, including pearl millet, to identify and characterize the biological function of PgDNAJ genes in pearl millet.
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Article
Open AccessEfficient signal sequence of mRNA vaccines enhances the antigen expression to expand the immune protection against viral infection
The signal sequence played a crucial role in the efficacy of mRNA vaccines against virus pandemic by influencing antigen translation. However, limited research had been conducted to compare and analyze the spe...
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Article
Open AccessAssociation between physical activity, peak expiratory flow, and cognitive function in aging: a cross-sectional analysis
The aging global population is experiencing escalating challenges related to cognitive deficits and dementia. This study explored the interplay between pulmonary function, physical activity, and cognitive func...
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Article
Open AccessDeep learning of mammogram images to reduce unnecessary breast biopsies: a preliminary study
Patients with a Breast Imaging Reporting and Data System (BI-RADS) 4 mammogram are currently recommended for biopsy. However, 70–80% of the biopsies are negative/benign. In this study, we developed a deep lear...
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Open AccessCross-site validation of lung cancer diagnosis by electronic nose with deep learning: a multicenter prospective study
Although electronic nose (eNose) has been intensively investigated for diagnosing lung cancer, cross-site validation remains a major obstacle to be overcome and no studies have yet been performed.
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Article
Clinical role of serum microRNA-155 in early diagnosis and prognosis of septic patients with acute kidney injury
Acute kidney injury (AKI) is a common complication in patients with sepsis, and early detection and timely treatment are crucial. This article aims to explore the clinical role of microRNA-155 (miR-155) in ear...
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Article
Open AccessIntegrative analysis of the metabolome and transcriptome provides insights into the mechanisms of lignan biosynthesis in Herpetospermum pedunculosum (Cucurbitaceae)
Herpetospermum pedunculosum (Ser.) C. B. Clarke is a traditional Chinese herbal medicine that heavily relies on the lignans found in its dried ripe seeds (Herpetospermum caudigerum), which have antioxidant and h...
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Rapid visual detection of Giardia duodenalis in faecal samples using an RPA-CRISPR/Cas12a system
Giardiasis is a common intestinal infection caused by Giardia duodenalis, which is a major economic and health burden for humans and livestock. Currently, a convenient and effective detection method is urgently n...
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Article
Open AccessBifurcation of Multiple Periodic Solutions for a Class of Nonlinear Dynamical Systems in \((m+4)\) -Dimension
In this paper, we introduce a curvilinear coordinate transformation to study the bifurcation of periodic solutions from a 2-degree-of-freedom Hamiltonian system, when it is perturbed in
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Article
Asymmetric scattering effect of solitary wave in a two-section composite granular chain
Granular chain serves as a fundamental component for controlling the nonlinear solitary wave propagation in acoustic metamaterials. The understanding of the nonlinear scattering at the mismatched interface pla...
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Open AccessDual-targeting tigecycline nanoparticles for treating intracranial infections caused by multidrug-resistant Acinetobacter baumannii
Multidrug-resistant (MDR) Acinetobacter baumannii (A. baumannii) is a formidable pathogen responsible for severe intracranial infections post-craniotomy, exhibiting a mortality rate as high as 71%. Tigecycline (T...
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Article
Improved Electron Distribution in Graphene Quantum Dots Carrier by F, N Co-Do** for Electrocatalytic ORR
Rising energy demand has forced to look for new ways to convert energy. Graphene quantum dots (GQD) has received extensive attention in many fields due to their low toxicity, abundant active sites, sound water...
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Article
Genetic lineage tracing identifies adaptive mechanisms of pancreatic islet β cells in various mouse models of diabetes with distinct age of initiation
During the pathogenesis of type 1 diabetes (T1D) and type 2 diabetes (T2D), pancreatic islets, especially the β cells, face significant challenges. These insulin-producing cells adopt a regeneration strategy t...
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Article
Open AccessImpairments of GABAergic transmission in hippocampus mediate increased susceptibility of epilepsy in the early stage of Alzheimer’s disease
Patients with Alzheimer’s disease (AD) are often co-morbid with unprovoked seizures, making clinical diagnosis and management difficult. Although it has an important role in both AD and epilepsy, abnormal γ-am...
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Article
Surgical techniques and effectiveness of laparoscopic resection of abdominal wall desmoid-type fibromatosis and defect reconstruction: a single-center retrospective analysis
Although the treatment of abdominal wall desmoid-type fibromatosis (DF) has evolved over the past decades, surgical treatment remains an important approach. Previously, surgeries for abdominal DF were mostly p...
