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Article
Open AccessDAXX drives de novo lipogenesis and contributes to tumorigenesis
Cancer cells exhibit elevated lipid synthesis. In breast and other cancer types, genes involved in lipid production are highly upregulated, but the mechanisms that control their expression remain poorly unders...
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Article
Two-Way Horizontal and Vertical Omics Integration for Disease Subtype Discovery
Disease subtype discovery is an essential step in delivering personalized medicine. Disease subty** via omics data has become a common approach for this purpose. With the advancement of technology and the lo...
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Article
Open AccessβArrestin2 Mediates Renal Cell Carcinoma Tumor Growth
Renal Cell Carcinoma (RCC) is one of the most lethal urological cancers worldwide. The disease does not present early clinical symptoms and is commonly diagnosed at an advanced stage. Limited molecular drivers...
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Reference Work Entry In depth
Early B-Cell Factors
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Article
Open AccessIntrinsic cellular signaling mechanisms determine the sensitivity of cancer cells to virus-induced apoptosis
Cancer cells of epithelial and mesenchymal phenotypes exhibit different sensitivities to apoptosis stimuli, but the mechanisms underlying this phenomenon remain partly understood. We constructed a novel recomb...
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Living Reference Work Entry In depth
Early B-Cell Factors
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Protocol
Identification and Characterization of Small-Molecule Inhibitors of Lysine Acetyltransferases
Lysine acetyltransferases (KATs) acetylate various proteins including histones, transcription factors, metabolic enzymes, and other cellular substrates. Protein acetylation significantly impacts protein stabil...
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Reference Work Entry In depth
Early B-cell Factors
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Reference Work Entry In depth
Early B-cell Factors
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Article
PCAF is a coactivator for p73-mediated transactivation
The tumor suppressor p53-related p73 shares significant amino-acid sequence identity with p53. Like p53, p73 recognizes canonical p53 DNA-binding sites and activates p53-responsive target genes and induces apo...
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Article
Gene Conversion Drives Within Genic Sequences: Concerted Evolution of Ribosomal RNA Genes in Bacteria and Archaea
Multiple copies of a given ribosomal RNA gene family undergo concerted evolution such that sequences of all gene copies are virtually identical within a species although they diverge normally between species....
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Article
Characterization of a Novel Class of Interspersed LTR Elements in Primate Genomes: Structure, Genomic Distribution, and Evolution
Retrovirus-like sequences and their solitary (solo) long terminal repeats (LTRs) are common repetitive elements in eukaryotic genomes. We reported previously that the tandemly arrayed genes encoding U2 snRNA ...
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Article
Molecular phylogenies based on ribosomal protein L11, L1, L10, and L12 sequences
Available sequences that correspond to the E. coli ribosomal proteins L11, L1, L10, and L12 from eubacteria, archaebacteria, and eukaryotes have been aligned. The alignments were analyzed qualitatively for shared...
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Chapter
The Evolution of Ribosomal Protein and Ribosomal RNA Operons: Coding Sequences, Regulatory Mechanisms and Processing Pathways
All extant life forms were derived from a single primordial ancestor that already had a DNA based genetic system and a well established transcription-translation apparatus. Evolutionary diversification driven ...
