-
Article
The Relationship Between Harmful Alcohol Use and Antiretroviral Non-adherence in People Accessing HIV Treatment in Cape Town, South Africa: An Event-Level Analysis
Harmful alcohol consumption can significantly compromise adherence to antiretroviral therapy (ART). Prior research has identified aggregate relationships between alcohol use and ART non-adherence, largely rely...
-
Article
Open AccessThe diagnostic odyssey of autism: a cross-sectional study of 3 age cohorts of children from the 2016–2018 National Survey of Children’s Health
Autism prevalence has increased rapidly in recent years, however, nationally representative estimates on the ages of first identification and intervention are out of date. Objectives: (1) To estimate the ages ...
-
Article
Older molecular brain age in severe mental illness
Psychiatric disorders are associated with accelerated aging and enhanced risk for neurodegenerative disorders. Brain aging is associated with molecular, cellular, and structural changes that are robust on the ...
-
Article
Open AccessDetecting survival-associated biomarkers from heterogeneous populations
Detection of prognostic factors associated with patients’ survival outcome helps gain insights into a disease and guide treatment decisions. The rapid advancement of high-throughput technologies has yielded pl...
-
Article
Pten-NOLC1 fusion promotes cancers involving MET and EGFR signalings
Inactivation of Pten gene through deletions and mutations leading to excessive pro-growth signaling pathway activations frequently occurs in cancers. Here, we report a Pten derived pro-cancer growth gene fusion P...
-
Article
Variable Selection in Threshold Regression Model with Applications to HIV Drug Adherence Data
The threshold regression model is an effective alternative to the Cox proportional hazards regression model when the proportional hazards assumption is not met. This paper considers variable selection for thre...
-
Article
Two-Way Horizontal and Vertical Omics Integration for Disease Subtype Discovery
Disease subtype discovery is an essential step in delivering personalized medicine. Disease subty** via omics data has become a common approach for this purpose. With the advancement of technology and the lo...
-
Article
Cisplatin-induced immune modulation in ovarian cancer mouse models with distinct inflammation profiles
The backbone of ovarian cancer treatment is platinum-based chemotherapy and aggressive surgical debulking. New therapeutic approaches using immunotherapy via immune checkpoint blockade, which have demonstrated...
-
Article
The Evolution of Estrogen Receptor Signaling in the Progression of Endometriosis to Endometriosis-Associated Ovarian Cancer
To investigate changes in estrogen receptor alpha (ERα) signaling during progression of endometriosis to endometriosis-associated ovarian cancer (EAOC) as a driver of malignant transformation. We procured tiss...
-
Article
Anti-PD-L1 prolongs survival and triggers T cell but not humoral anti-tumor immune responses in a human MUC1-expressing preclinical ovarian cancer model
Monoclonal antibodies that block inhibitory immune checkpoint molecules and enhance anti-tumor responses show clinical promise in advanced solid tumors. Most of the preliminary evidence on therapeutic efficac...
-
Article
Open AccessThe molecular landscape of premenopausal breast cancer
Breast cancer in premenopausal women (preM) is frequently associated with worse prognosis compared to that in postmenopausal women (postM), and there is evidence that preM estrogen receptor-positive (ER+) tumo...
-
Article
Open AccessIncorporating functional annotation information in prioritizing disease associated SNPs from genome wide association studies
With recent advances in genoty** and sequencing technologies, many disease susceptibility loci have been identified. However, much of the genetic heritability remains unexplained and the replication rate bet...
