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Article
Open AccessInpatient and outpatient treatment patterns of cancer-associated thrombosis in the United States
Low molecular weight heparins (LMWHs) and direct oral anticoagulants (DOACs) are among the recommended treatment options for cancer-associated thrombosis (CAT) in the 2019 National Comprehensive Care Network g...
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Article
A simulation model for capacity planning in community care
Sustainable health care requires the building of sufficient capacity in order to ensure that patients receive the right care in a timely fashion. Often the efficient use of available capacity at one level (ie,...
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Article
Open AccessGenetic variant predicts bevacizumab-induced hypertension in ECOG-5103 and ECOG-2100
Bevacizumab has broad anti-tumour activity, but substantial risk of hypertension. No reliable markers are available for predicting bevacizumab-induced hypertension.
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Article
Anchors for the cosmic distance scale: the Cepheid QZ Normae in the open cluster NGC 6067
Cepheids are key to establishing the cosmic distance scale. Therefore it’s important to assess the viability of QZ Nor, V340 Nor, and GU Nor as calibrators for Leavitt’s law via their purported membership in t...
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Article
On the metallicity dependence of classical Cepheid light amplitudes
Classical Cepheids remain a cornerstone of the cosmic distance scale, and thus characterizing the dependence of their light amplitude on metallicity is important. Period-amplitude diagrams constructed for long...
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Article
Open AccessA longitudinal study of serum insulin and glucose levels in relation to colorectal cancer risk among postmenopausal women
It is unclear whether circulating insulin or glucose levels are associated with increased risk of colorectal cancer. Few prospective studies have examined this question, and only one study had repeated measure...
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Article
Open AccessThe inhibition of Bid expression by Akt leads to resistance to TRAIL-induced apoptosis in ovarian cancer cells
Epithelial ovarian cancer (EOC) cells often show increased activity of the PI3K/Akt pathway. In addition, we have previously shown that EOC ascites induce Akt activation in the tumor necrosis factor-related ap...
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Article
Ovarian cancer ascites protects from TRAIL-induced cell death through αvβ5 integrin-mediated focal adhesion kinase and Akt activation
Interactions between ovarian cancer cells and the surrounding tumor microenvironment are not well characterized. We have earlier shown that ovarian cancer ascites induces Akt activation and protect tumor cells...
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Article
D133P53, directly transactivated by p53, prevents p53-mediated apoptosis without inhibiting p53-mediated cell cycle arrest
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Article
Sop proteins can cause transcriptional silencing of genes located close to the centromere sites of linear plasmid N15
Stable inheritance of bacterial chromosomes and low copy number plasmids is ensured by accurate partitioning of replicated molecules between the daughter cells at division. Partitioning of the prophage of the ...
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Article
The p53 knowledgebase: an integrated information resource for p53 research
The p53 tumor suppressor protein plays a central role in maintaining genomic integrity by occupying a nodal point in the DNA damage control pathway. Here it integrates a wide variety of signals, responding in ...
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Article
Development of CDK inhibitors as cancer therapeutics
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Compliance with pharmacological therapy in hypertension: can we do better, and how?
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Article
Develo** new treatments for breast cancer
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Article
Structural Organization and Control of Expression of the sop Operon of Linear Plasmid Prophage N15
Stable inheritance of bacterial chromosomes and low-copy-number plasmids depends on the active partition of replicated molecules between daughter cells. The partition mechanism is well known for circular plasm...
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Article
p53: 25 years of research and more questions to answer
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Article
Ethnic differences in blood pressure and the prevalence of hypertension in England
The objective of this study was to examine the prevalence of hypertension and mean blood pressures among Afro-Caribbeans and South-Asians in England compared with Caucasians. Data from the Birmingham Factory S...
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Article
Quantitation of sequence copy-number changes in genomic DNA through GenoSensor-based comparative genomic hybridization
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Article
Genetic basis of the MbrC “ploidy” phenotype in Escherichia coli
The mbrC17 mutation in Escherichia coli had been shown to cause conditional growth defects and an increase in the quantity of DNA per cell. The present work was aimed at identifying the mutation. Sequencing show...
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Article
Prognostic significance of p53 overexpression in primary breast cancer; a novel luminometric immunoassay applicable on steroid receptor cytosols
A novel quantitative luminometric immunoassay (LIA) has been developed for the measurement of wild-type and mutant p53 protein in extracts from breast tumour tissue. The LIA was found to yield reliable estimat...
